A novel water-soluble vitamin E derivative protects against experimental colitis in rats.
N Yoshida, T (Takeo) Yoshikawa, T Yamaguchi, Y Naito, T Tanigawa, H Murase, M Kondo
This study was designed to investigate the effects of water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), on experimental colitis in rats. Colitis was induced in male Wistar rats weighing 200 grams using an enema of trinitrobenzene sulfonic acid (TNBS) dissolved in 50% ethanol; 1 ml of TMG dissolved in physiological saline (0.2 mg/ml, 2 mg/ml, 20 mg/ml) was ...
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