You may consider checking your methylation profile and try the supplements to address genetic snps, using Dr. Amy Yasco's detailed protocol developed for neuro dz and autism, but I imagine should help all chronic disease- at Holistic Health International.
For example if CBS enzyme defect, can get sulfite toxicity...
correction of methylation helps detox
check urine organic acids from Great Plains Lab for arabinose, indicating yeast, and treat the yeast with naturpathic doc
Gluten free, casein free, nightshade free, glutamate free diet
alternate good probiotics/ VSL3 DS
adequate vitamin D levels
relaxation/yoga/ adequate sleep