you know it's funny you should mention this...i think i share the same issue you have.....it feels like a tender pain almost like my skin is burning i think it is the liver but who knows...i only did one P&B shake so far ...and it started happening several hours later maybe about 8 hours ....i thought it is weird still there 24 hours later and i am getting ready to drink another shake...BUT i did just come off The Master Cleanse (10 days) about a week ago...i am totally thinking it is the liver i know where the pain should be i had my gallbladder removed...but unsure why...i am thinking of drinking one of those spicey lemonades'(from the master cleanse) in the morn....if it doesnt go away...the lemons are detoxifying to the liver ..... well i hope someone will tell us or something:))