Re: Minimalist Yeast Abatement Protocol

The mobility of Candida Albicans in terms of morphic shifting between budding to hyphal and back to budding in response to temperature, pH, nutrient depletion, antifungal attack, immune system challenge, and biochemical changes to its environment has been well studied. This means that it certainly has access to other nutrient-rich areas in the body that suit its colonization requirements. The "eye floater" phenomenon suggests that the yeast has availed itself of this ability. But at the same time it must have techniques for coordinating and self-limiting its own proliferation in multiple colonization sites so as not to overwhelm its host.

Although the interaction of Candida Albicans with its host's metabolism is quite complex, the evidence that we have been examining here implies that acetaldehyde is not just a problem but THE problem in the case of an astonishing variety of disease states. Furthermore, assuming that self-limiting polysystemic colonization is indeed the case, then we can look for acetaldehyde-related connections to symptoms outside of the usual gastrointestinal locale, perhaps at the blood-brain barrier, for example.

Since the source of this toxic substance is now known to be a fungus (the yeast Candida Albicans), then why not just take a course of potent antifungals and be rid of it? There are certainly life-threatening infectious situations in immunosuppressed patients where an antifungal drug such as amphotericin B or fluconazole is imperative. However, the mode of action of antifungal drugs seeks to selectively eliminate fungal cells without targeting human cells and herein lies a problem. Both fungal and mammalian cells are eukaryotes (having a nucleus) and share more similarities at the molecular level than say human cells and bacterial cells that are prokaryotes (without a nucleus). This mean that the side effects from antifungal drugs may be almost as devastating to the host cells as they are to the yeast cells that need to be eliminated.



If we have learned anything from the indiscriminate use of Antibiotics over the past decades, it should be that the organisms that we seek to destroy in this manner do not succumb passively to these threats to their existence. The appearance of antibiotic-resistant bacterial strains attests to this. A guns-blazing approach to attempt to rid everybody of Candida Albicans will surely only result in the development of more antifungal-resistant strains.

Candida Albicans has entrenched itself in the human host. It can camouflage its cellular surface with receptors that make it look more like self rather than non-self to the immune system.

See Gilmore et al. http://jid.oxfordjournals.org/content/157/1/38.short

It has several different morphic states that it can use to avoid extermination. As a biofilm it can cover itself with drug resistant slime. In its hyphal state it is mobile and can seek out new more suitable locales by burrowing through tissue. As a budding yeast, its toxic byproduct, acetaldehyde, blunts the immune response to its presence, possibly by throttling the action of the thyroid.

See Acetaldehyde + thyroid //www.curezone.org/forums/fm.asp?i=1955669

Leave one yeast cell capable of budding and it can re-establish its colonization all over again.

Instead of trying to eliminate it, something that verges upon impossibility, strategies need to be employed that reduce it to a relatively benign commensal that no longer poses a threat to health. This must be accomplished using techniques that are powerful enough to have a significant impact yet gentle enough that they can be continued indefinitely.

First and foremost, the acetaldehyde that it releases must be neutralized. Although they didn't know at the time how it was working, the ad hoc clinical trial of Wondro (sulfurated flax oil) in the early 1900's demonstrated that this step, in and of itself, produces remarkable results. And this can be done by simply intercepting this toxic substance as a yeast waste byproduct in the throat and the gut before it encounters human tissue -- something that is non-provocative from the perspective of a yeast cell.

See Wondro for one //www.curezone.org/forums/fm.asp?i=1960885

See Proposed Wondro alternative //www.curezone.org/forums/fm.asp?i=1947895

In tandem with acetaldehyde scavenging the long-term production of acetaldehyde at its source needs to be reduced. But this is trickier because any direct assault on the yeast cells themselves may provoke avoidance reactions such as a budding to hyphal morphic shift.

Candida Albicans has acquired a sufficient arsenal of assault and avoidance techniques (acetaldehyde, phospholipase, biofilm slime, polymorphism) that should make it far more rapidly and fatally virulent than it actually is. Although its presence in everyone has long been known, instead of being identified as the cause of chronic conditions, it has managed to remain beneath the clinical radar, being relegated to a consequence of disease rather than an instigator. Why?

As a fungus it is totally dependent upon its host for its own livelihood. This implies that it must have evolved self-limiting techniques that allow for the continued existence of both itself and its host, even if the conditions that it precipitates through acetaldehyde excretion are potentially debilitating.

See White et al. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0030184

If so, perhaps we can tap into these very same techniques to facilitate a gradual (non-drug) approach to reducing its colonization in addition to scavenging its toxic byproduct acetaldehyde.
Tweet