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#147951
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- Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,452
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This is a reply to # 1,945,118When it was produced in large batches, the sulfur and oil were mixed in 60-gallon stainless steel kettles with intense heat (500-600 F) applied for approximately 1 hour before the reaction occurred. This has not been done since the early 1950's. For a batch larger than single dosage adequate ventilation of the production area is paramount. The proof of concept experiment to see if it could be made in single dosage quantities used a 900W microwave on HIGH for about 5 minutes. It is immediately obvious when the reaction has occurred because of the color change.
This particular substance had not been unknown to the medical practice of its time as references to similar concoctions called "balsam of sulphur" and "sulphurated linseed oil" have been found in "Dunglison, R., Medical Lexicon, A Dictionary of Medical Science, 1866" and "Maisch, J. M., A Universal Formulary: Preparing And Administering Officinal and Other Medicines, 1874".- Re: Minimalist Yeast Abatement Proto... Tizona
12 y
19,539
This is a reply to # 1,945,130do you know any place online where you can purchase the precipitated sulphur, USP in small amounts?
The smallest amount I could find anybody selling it in 500 g for about $75- Re: Minimalist Yeast Abatement Proto... #147951
12 y
24,098
Lugol’s Iodine Free S&H
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Candida Detox
Mucoid plaque = Parasites = Candida
Remove them all!
This is a reply to # 1,945,145http://www.medshopexpress.com/10005090.html
has it in 4oz quantities for $4.37. Powdered sulfur is quite commonly used topically as a chigger repellant.- Re: Minimalist Yeast Abatement Proto... Tizona
12 y
19,646
MoreThis is a reply to # 1,945,151okay great, thanks a lot
I'm going to order some and try to make a little. We'll see how it goes- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,397
Lugol’s Iodine Free S&H
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This is a reply to # 1,945,339Page 18, Lethbridge Herald, September 4, 1937 - Newspaper Archive
http://www.newspaperarchive.com/lethbridge-herald/1937-09-04/page-18
If you are interested in reading Page 18, Lethbridge Herald, September 4, 1937, ... Lethbridge by Remedy Brocket Resident Effects of Wondro For many years a ...
Page 8, Lethbridge Herald, December 3, 1937 - Newspaper Archive
http://www.newspaperarchive.com/lethbridge-herald/1937-12-03/page-8
If you are interested in reading Page 8, Lethbridge Herald, December 3, 1937, ... of The balance represented sundry ECZEMA GOES WHEN WONDRO USED ...
Page 15, Lethbridge Herald, October 23, 1937 - Newspaper Archive
http://www.newspaperarchive.com/lethbridge-herald/1937-10-23/page-15
If you are interested in reading Page 15, Lethbridge Herald, October 23, 1937, ... TO EYE Had Stomach Trouble For Feels Like New Man After Taking Wondro If ...- Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,102
Lugol’s Iodine Free S&H
J.Crow’s® Lugol’s Iodine Solution. Restore lost reserves.
Feel Like The Wind!
Be light and breezy now!
End Constipation Now
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Hulda Clark Parasites Cleansing Tincture, 2 oz, 4 oz, 8 oz, and 16 oz
This is a reply to # 1,945,488As good as Wondro was in its time, it may be possible to concoct an alternative based on its mode of action and the ideas raised in this discussion.
OBJECTIVES:
O sulfur must be present as an attractive irreversible binding site for acetaldehyde
[Elemental sulfur exists as a tight octatomic ring. This may not provide as much of an externally attractive electronegative profile for acetaldehyde binding as a sulfur atom that is part of another molecular structure. This would explain why the results obtained with Wondro (a sulfur-bearing compound) were superior to "sulfur and molasses" (a mixture). Elemental uncombined sulfur is also a potential irritant to mucous membranes.]
O consistency of the delivery mechanism should be able to persist in the intestinal villi
[Something that is water soluble may not persist long enough to be available for binding when the yeast releases its acetaldehyde. Ideally the substance should be able to coat the external membrane of the budding yeast cells as well.]
O heating should be avoided
[When anything containing essential fatty acids is heated with sulfur, the unsaturated carbon atoms are vulcanized. Although the result may be biologically neutral and not harmful, the health benefits of the essential fatty acids are lost.]
O easy and quick to prepare
[A single dose of Wondro requires 5 minutes of microwave heating time and a few minutes of cooling time before it can be ingested.]
O palatable for ingestion
[Wondro has a distinctive odor and flavor that some may find difficult to adjust to.]
PROPOSED WONDRO ALTERNATIVE:
o 2 tbsp cold-pressed flax oil
o 2 500 mg timed-release N-acetyl-L-cysteine (RESBID)
[powdered contents of two opened capsules]
Combine the oil and the powder in an egg cup and whiz with a milk frother to emulsify. Consume in the morning before eating.
The result is a suspension of combined sulfur atoms (part of a conditionally-essential amino acid derivative) in healthy essential fatty acids that will coat the intestinal surfaces and yeast membranes. It would be immediately available for acetaldehyde binding to prevent this toxin from migrating into the blood stream. There may, of course, be some trade off in efficacy here. Each sulfurated linoleic fatty acid (omega-6) molecule in Wondro potentially has two sulfur-rich acetaldehyde binding sites and each sulfurated linolenic fatty acid (omega-3) molecule potentially has three, while N-acetyl-L-cysteine has only one per molecule.
It may take one or two months (the surface area of the intestinal region is on the order of a tennis court) before significant reduction of yeast-related symptoms is achieved. Other yeast abatement strategies should be followed as well (as described in the reference "Astrophysiology...and Yeast") to reduce the amount of acetaldehyde being produced.
-
Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,412
MoreThis is a reply to # 1,947,895Initial testing with timed release N-acetyl-L-cysteine (Resbid) emulsified in flax oil:
o slightly bitter taste upon ingestion but no adverse reactions
o overall improvement in taste and appetite
This protocol has the potential of thinly coating the entire alimentary canal in the same manner that Wondro did in one of the major areas of yeast overgrowth, from mouth (coated tongue) to anus (pruritus).
NAC has one sulfur atom suitably positioned for acetaldehyde binding and can capture one acetaldehyde per molecule of NAC.
Linolenic acid (an omega-3 fatty acid) is one of the constituents of flax oil. The sulfurated form which appears when flax oil is heated together with elemental sulfur is referred to here as wondrenic acid (after Wondro). It potentially has three clusters of sulfur atoms:
There are more sulfur atoms per molecule (i.e. more barbs on the acetaldehyde bait hook)...but flax oil has other non-sulfurated constituents as well. The NAC used here is more concentrated with the timed release mechanisms of Resbid (Ecological Formulas) emulsified into the flax oil. As a result the total number of sulfur atoms available for acetaldehyde binding over time in emulsified Resbid might be comparable to Wondro, delivered in a mode of similar viscosity.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,116
Lugol’s Iodine Free S&H
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This is a reply to # 1,953,937We're not just talking about a few acetaldehyde molecules here and there. To put things into perspective let's see what happens in the worst case scenario if budding yeast in the gut gets a hold of and metabolizes an entire teaspoon of Sugar (sucrose).
In one teaspoon of sugar:
1 tsp sucrose X 4 g / tsp X 1 mol / 342.3 g X 6.02 x 10^23 molecules / mol
equals about 7 x 10^21 molecules of sucrose.
There is one molecule of glucose for each molecule of sucrose and each molecule of glucose yields two molecules of pyruvate which can be metabolized by pyruvate decarboxylase in yeast into one molecule of acetaldehyde and one molecule of carbon dioxide (the gas/bloating symptom).
1 tsp sucrose = 7 x 10^21 X 1/1 X 2/1 X 1/1 = 14,000,000,000,000,000,000,000
There are potentially 14 sextillion molecules of acetaldehyde (about 1 gram) that can be released from Candida Albicans yeast cells for each teaspoon of Sugar that they are fed! Twenty-five percent of the ingested Sugar may emerge from the reaction as a harmful substance. Each and every one of these acetaldehyde molecules that isn't apprehended can cause damage to the body in any number of different ways.
The single dose Wondro formula uses about 1/2 teaspoon (5 grams) of elemental sulfur. Assuming that the heating process combines all of the available sulfur into the unsaturated fatty acid bonds in the flax oil, then
5 g S X 1 mol / 32.065 g X 6.02 x 10^23 atoms / mol
equals about 94 x 10^21 or 94 sextillion atoms of "combined" sulfur in the resulting compound.
About 50% of these (47 sextillion) may be available for acetaldehyde binding. This supposition is supported by a naturally occurring process in the body in the pyruvate dehydrogenase reaction portion of the citric acid cycle where acetyl-coenzyme A is formed:
http://www.brookscole.com/chemistry_d/templates/student_resources/shared_reso...
As an intermediate step in this reaction, acetaldehyde breaks into the disulfide bond in lipoic acid. This may be very similar to what happens to the sulfurated fatty acids in flax oil when they encounter acetaldehyde in the gut.
[Question: Would the second -SH structure be capable of assimilating another acetaldehyde or not?]
It is important to note here that although the body does indeed use the acetaldehyde configuration in the production of acetyl-coenzyme A, it only does so when acetaldehyde is "immobilized" safely within an enzyme. It doesn't allow it to float freely in the cellular milieu. The intent of a good acetaldehyde scavenger, then, would be to similarly immobilize rogue molecules of acetaldehyde released in unexpected locales.
As a comparison the suggested Wondro alternative protocol uses two 500 mg capsules (1 gram) of N-acetyl-L-cysteine which may yield up to:
1 g NAC X 1 mol / 163.19 g X 6.02 x 10^23 molecules / mol
equals about 3.7 x 10^21 or 3.7 sextillion atoms of sulfur in the emulsion, since there is one sulfur atom per molecule of NAC with all of these potentially available for acetaldehyde binding.
Based on these calculations the Wondro formulation would be at least 10 times as potent an acetaldehyde scavenger as the NAC emulsion but the NAC emulsion is easier to make (no heating) and to take (odorless).
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,087
This is a reply to # 1,954,934In light of the previous post, trying to starve the yeast out of existence in your system by depriving it of the Sugar that it likes and needs might seem like a reasonable approach. In fact, Sugar cravings are one of the indicative signs that there is an overgrowth of yeast on board, intercepting what the body needs for its own energy requirements. If a significant proportion of sucrose in the diet emerges as acetaldehyde, reducing the amount of raw material for yeast metabolism is certainly a factor in recovery.
However, too strict a diet in this regard may be counterproductive. It is impossible to remove the yeast from your system by simply starving it to death. You will be a casualty before it is. Candida Albicans is an incredibly robust and versatile organism. Fungi, in general, are totally reliant on other hosts for their energy requirements and have become adept at finding ideal environments, waiting out times of short supply, and migrating to other locales in search of their sustenance. When nutrients are not forthcoming, Candida Albicans can go dormant for extended periods waiting or it can shift from a budding phase to a hyphal growth mode secreting the enzyme phospholipase to burrow its way through tissue.
The individuals who described their experiences in the Wondro testimonials pamphlet did not implement any strict dietary protocols to achieve their personal remarkable results. All they did was consume a daily dosage of sulfurated flax oil, which in light of what is now known, looks like a highly efficient acetaldehyde scavenger. This focuses the spotlight on this toxin as perhaps being the most significant factor of yeast metabolism in the etiology of a wide variety of disease states.
Since we now have a much clearer idea of where this toxin is coming from (commensal yeast) and how this yeast manages to increase its stake in the body ( Antibiotic selective removal of intestinal bioflora, for example), we should be able to do at least as well, hopefully better, at managing yeast overgrowth and its deleterious effects.
Any effective yeast abatement protocol must at least attempt to:
• scavenge and neutralize any acetaldehyde being produced
• stop the production/release of acetaldehyde from the yeast
• reactivate the body's own innate immune response to reduce yeast populations
• supply the necessary resources to the innate immune system to perform this task
• reduce the level of viable yeast cells capable of producing acetaldehyde
• repopulate the gut with beneficial bacteria for competitive exclusion
Furthermore, it should be able to do these things without too severe a dietary regimen and without side effects that prevent the protocol from being continued indefinitely.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,244
This is a reply to # 1,955,272Anything with 94 sextillion atoms of sulfur for every two tablespoon dosage is going to have a rather pungent odor, even if the sulfur is buried in the fatty acids of flax oil. At some point in its production history in the first half of the twentieth century the mode of Wondro consumption was changed from a liquid to gel capsules for this very reason. Although it still appeared to work, there was a lingering perception amongst those who made it and took it that it just wasn't quite as effective in this form.
Fast forward to today...have your ever eaten a Caesar Salad with a potent garlic-laced dressing, only to wake up in the morning with furry teeth syndrome?
Is there a connection here?
Assuming that Wondro worked its magic by scavenging acetaldehyde and that the acetaldehyde is emanating from the Sugar metabolism of commensal yeast, then the historical change in efficacy could be explained by the fact that the capsules missed the initial portion of the alimentary canal -- the esophageal lining. This implies that a significant proportion of the acetaldehyde to blood stream poisoning of the body may occur from this region even before the stomach and intestines because commensal yeast finds this region an ideal colonization locale. Here it is "first in line" for ingested nutrients prior to the rather harshly acidic environment of the stomach.
It is generally accepted now that a coated tongue, something that used to be one of the first things checked as an indicator of good health, is a sign of yeast overgrowth. Ingestion of an antifungal such as the garlic in the salad dressing, which coats the esophageal lining on the way to the stomach, may precipitate an avoidance maneuver shift of the yeast in this area away from the antifungal, that is, towards the mouth (tongue and teeth) with the furry teeth syndrome the net result.
This has implications for any yeast abatement protocol in terms of the delivery mechanism of both acetaldehyde scavengers and antifungal agents. Capsules may not be the best mode for either. The flax oil emulsified NAC conforms to this and should be more effective than the encapsulated form. Garlic capsules similarly should be broken open and stirred into some liquid mixture before ingestion.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
20,261
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This is a reply to # 1,955,421If the assumption made in the previous post is correct: that there may be significant damage inflicted upon the body from yeast colonization and release of acetaldehyde in the esophageal lining, something that is missed by encapsulated antifungals and acetaldehyde scavengers; then there should be other clues that support this.
What is situated immediately adjacent to this region? The thyroid gland is located in the neck wrapped around the esophagus! This endocrine gland produces hormones that control the metabolism of almost every tissue in the body including how they use energy, make proteins, and their sensitivity to other hormones.
Dr. William G. Crook in his 1980's book, "The Yeast Connection", was convinced that candidiasis and thyroid abnormalities were related. Whenever symptoms occur simultaneously, however, there is always the "chicken and egg" debate about which came first. Does Candida Albicans cause impairment of thyroid function or does low thyroid activity allow yeast to take hold? Perhaps there is a vicious cycle here where both aspects are true.
The acetaldehyde that is released by budding yeast metabolism in the esophageal lining is such a small molecule that it would have no trouble diffusing across the esophageal lining right into the proximity of the thyroid gland. The thyroid gland produces and releases its hormones in response to circulating levels of TSH released by the pituitary gland. The TSH molecule alerts thyroid cells that more of their T3 and T4 hormones are needed by docking in a thyroid cell TSH receptor, an integral membrane protein called a G Protein-Coupled Receptor. As described in more detail in:
//www.curezone.org/forums/fm.asp?i=1955511
these types of receptors may be exquisitely sensitive to rogue molecules of acetaldehyde. The damage to the structurally and functionally essential disulfide bridge inflicted upon the receptor by acetaldehyde may be sufficient to stop the receptor from responding to the TSH signals to produce thyroid hormones. When thyroid hormones are low, the immune system becomes sluggish and is less able to respond to yeast cells that are inhabiting the body. Yeast levels increase with more acetaldehyde production which further impairs thyroid function and the vicious cycle is in place.
Autoimmunity often plays a role in thyroiditis where the immune system begins to attack the cells of the thyroid gland, something that again impairs its ability to function and produce its essential hormones. Is there a link to acetaldehyde from yeast here as well?
Acetaldehyde is a highly reactive molecule. It has an electrophilic carbon atom that likes to latch onto any body structures in its path that present an attractive binding site. Exposed sulfur atoms and amine groups are plentiful and particularly vulnerable to this type of attack. These protein "adducts" are now unrecognizable to the immune system and may trigger an immune response because the body now considers these damaged cells to be "non-self" rather than "self".
Yeast colonization in the esophagus that often reveals its presence as a coated tongue, furry teeth, or in its advanced infectious state as thrush literally has a "strangle hold" on the metabolism of the body through its ability to impair thyroid function.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,902
This is a reply to # 1,955,669Many of the Wondro testimonials (circa 1930's) spoke of relief from "stomach troubles" that were chronic and apparently untreatable. It has been well established that increased intestinal permeability (leaky gut) is associated with the pathology of numerous diseases:
• inflammatory bowel diseases such (eg. Crohn's and ulcerative colitis)
• chronic inflammatory arthritides
• acne
• psoriasis
• eczema
• urticaria
• irritable bowel syndrome
• autism
to name just a few. Is leaky gut the cause, an effect, or a consequence of something common to all of these conditions?
In a sense the gastrointestinal tract from mouth to anus can be considered to be "outside" of the body with special structures (intestinal walls) and processes (digestion) in place to allow it to select what it needs and dispose of everything else as waste. The "inside" of the body is a much more controlled environment that needs to be protected from the ingested material being processed and disposed of. This is maintained by cells that are conformed in "tight junction" interactions where their membranes are sealed together by multiple strands of special protein complexes that form a barrier that is virtually impermeable to fluids.
Acetaldehyde exposure, as studied in relation to alcoholism where it is a known toxic byproduct of excess alcohol consumption, can result in the disassembly of the proteins in the junctional complex. In other words, acetaldehyde can punch holes in the intestinal wall = leaky gut syndrome!
See Basuroy et al. http://www.ncbi.nlm.nih.gov/pubmed/15718285
Acetaldehyde that stems from ethanol metabolism appears in the liver where aldehyde dehydrogenase enzymes are prepared to cope with it (within reasonable concentration limits) and turn it into harmless acetic acid. Acetaldehyde that is released in the gut by yeast metabolism immediately adjacent to the intestinal cells forming the tight junction complexes is a surprise to the body that it cannot deal with.
The first steps in the investigation of a crime scene involve the close scrutiny of the immediate surroundings including the inhabitants residing nearby. Again we have a direct link between a toxic agent (acetaldehyde), capable of causing permeability disruption; with a source (Candida Albicans), a commensal resident in the region of the damage; and a scavenger of this toxin (sulfurated flax oil) that could account for the dramatic results obtained by the testimonial authors of past years when they took Wondro.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,202
This is a reply to # 1,956,265Although the symptoms and diseases are as different as night and day, there is a common failure pattern here. The miniscule size of acetaldehyde is allowing it access to places where it shouldn't be and its reactivity is allowing it to bond to configurations where it doesn't belong. Then, once it reacts, it remains there, impairing the structure or function of the biological entity that was unfortunate enough to be exposed to it. Furthermore, it does this in a clandestine fashion since its two carbon, four hydrogen, and one oxygen atoms just blend into the landscape without exposing themselves to analysis like a heavy metal ion would.
Other healing regimens ("Food Is Your Best Medicine" by H. G. Bieler, MD, 1966) have embraced the theory that "...disease is caused by a toxemia which results in cellular impairment and breakdown…" without clearly realizing what it was or where it was coming from. C. O. Truss, MD ("The Missing Diagnosis", 1976) has expanded upon this by giving this toxin a name, "acetaldehyde", and a source "Candida Albicans" so that the nature of the damage can be characterized and rectified.
If the Wondro message -- that an amazing variety of apparently unrelated disease processes can respond to something as simple as a daily dose of an exceptionally potent but metabolically benign oral acetaldehyde scavenger -- is true, then it implies that every disease condition that has remained a conundrum to modern medicine should be re-examined from an acetaldehyde toxicity perspective. Even the prognosis of diseases that are well understood and treatable may improve if the impact of this toxin is removed from the background.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,526
This is a reply to # 1,959,826Candida Albicans yeast as a mobile commensal fungus tends to gravitate towards regions of the body where it has a nutrient-rich supply of resources and also where it is able to exert a certain degree of host-control. The upper region of the esophagus adjacent to the thyroid satisfies both of these constraints. Entrenched there Candida Albicans has first choice of any ingested materials before they descend into the somewhat harsh acidic environment of the stomach. Also, possibly via acetaldehyde-mediated suppression of thyroid response to its activating hormone TSH, yeast colonization in this region can down-regulate the response of the immune system to its presence.
See acetaldehyde+GPCRs //www.curezone.org/forums/fm.asp?i=1955511
and, Schaefer et al. http://www.fasebj.org/content/25/1/29.full
If this supposition is true, then there should be other biomarkers of its colonization in this region.
Sore throats are a common occurrence with millions of emergency department instances of throat-related cases in the United States every year. The most common cause is viral infection. But what makes the throat and adjacent tonsils so vulnerable to infection?
If acetaldehyde in the gut can disrupt the tight junctions proteins in the intestinal wall leading to "leaky gut", then yeast-released acetaldehyde in the esophagus could similarly alter the epithelial permeability in this sensitive region leading to "leaky throat" with inflammation, soreness, and susceptibility to infection (classic symptoms of sore throat) the result.
See acetaldehyde+leaky gut //www.curezone.org/forums/fm.asp?i=1956265
A connection between the integrity of tight junction proteins and the common condition of acid reflux has also been established:
See Asaoka et al. http://www.ncbi.nlm.nih.gov/pubmed/16143882
A sneeze is an autonomic reflex used by the body as a first line of defense in an attempt to physically clear invading material including viral activity from the respiratory passages. Budding activity of yeast and release of acetaldehyde will increase after the consumption of certain foods. If there is yeast-induced acetaldehyde irritation in the esophageal tissues potentially leading to loss of tight junction integrity, is acid reflux a similar autonomic response to attempt to eliminate the pathogenic behavior by exposing whatever is causing the damage to the acidic environment of the stomach?
Recent studies have demonstrated a role for the tonsils in the production of immune system T-cells:
See McClory et al http://www.jci.org/articles/view/46125
elevating the utility of these often-infected and often-removed lymph nodes at the top of the throat from just passive blocking of inhaled or ingested pathogens to an active participation in the systemic biochemistry of the immune system.
Aldehyde fuchsin intensely stains tonsil tissue:
See Sunami-Kataoka et al. http://www.ncbi.nlm.nih.gov/pubmed/11838713
indicating that these endothelial cells would be exquisitely sensitive to attack by acetaldehyde molecules released by budding yeast metabolism.
This model of yeast-produced, acetaldehyde-mediated disruption of both the tight junction proteins in the lining of the esophagus and of the epithelial cells of the tonsils may explain why steeped garlic tea, an antifungal (i.e. anti-yeast), is a frequently recommended home remedy for sore throats. Furthermore, it elucidates why a liquid acetaldehyde scavenger such as Wondro or emulsified NAC is more efficacious than an encapsulated one (something that bypasses this vulnerable region completely on its way to the stomach).- Re: Minimalist Yeast Abatement Proto... #147951
12 y
18,970
Lugol’s Iodine Free S&H
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Feel Like The Wind!
Be light and breezy now!
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Hulda Clark Parasites Cleansing Tincture, 2 oz, 4 oz, 8 oz, and 16 oz
This is a reply to # 1,960,577There are conflicting reports on the web about the usage of garlic as a home remedy for heartburn. For some it seems to be a trigger and for others the answer to their quest for relief. Assuming that yeast in the throat and esophagus has something to do with the condition (see previous post), we may be able to rationalize both types of experience.
Remember that we are not dealing with a passive organism here. Yeast is prepared to fight when antifungally challenged (e.g. by garlic). One of the ways it does this is to shift morphology from a budding yeast into an invasive hyphal form,
See budding/hyphal yeast //www.curezone.org/forums/fm.asp?i=1955272
that is capable of penetrating human cellular membranes by expressing one or more of the enzymes in the phospholipase group, something that is also found in snake venom and bee stings.
See Niewerth et al. http://www.ncbi.nlm.nih.gov/pubmed/11766099
For epithelial cells already damaged and sensitized by acetaldehyde emitted by yeast in this region, this type of invasive penetration may exacerbate the damage already in place and be an additional trigger for acid reflux.
Several sore throat remedies have a sweet component such as honey (e.g. olive oil, lemon, and honey) that may be included for this very reason -- to entice yeast back into its budding form. The long-term problem with this is that the yeast goes back to producing acetaldehyde which is deleterious to the tight junction proteins that seal the esophageal lining.
Therein lies the catch-22 host-control enigma that exists with yeast colonization. If you give it what it wants, it can damage the body (acetaldehyde toxicity symptoms). But, if you don't give it what it wants, it can shift strategies and damage the body some more (phospholipase degradation of tissue), perhaps with symptoms that were worse than before.
This may be why novel combinations such as honey, garlic and apple cider vinegar for heartburn are popular. Adding an acetaldehyde scavenger to the liquid mixture might make it even more effective.
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,846
This is a reply to # 1,960,846Most people have polysystemic Candida Albicans "colonization" without manifesting the overt clinical symptoms of fulminating "candidiasis", something that is medically acknowledged to be a serious and potentially fatal condition in immunocompromised patients. Since conventional wisdom relegates Candida Albicans to being a "harmless" commensal resident of the gastrointestinal tract and troublesome but not pathogenic causal agent of vaginal yeast infections, is there any evidence to support the controversial statement that yeast in the body is everywhere in everyone?
More than a few have noticed the striking similarity between the mycelial growth form of Candida Albicans as shown below:
and the ultrastructure of "eye floaters" that drift unobtrusively across your field of vision. Does this mean that these individuals are actually observing Candida Albicans that has "escaped" from the expected locales where it can normally be found?
The vitreous humor of the eyes is the clear gel that fills the cavity between the lens and the retina. Although it is mostly water it has a viscosity two to four times greater than water and can firmly support the surrounding elements of the eyeball. It is supposed to be completely transparent, but anything that is suspended in the fluid may be visible because of the refractive shadows that are projected upon the retina.
The turgidity of the vitreous humor is supplied by its content of hyaluronic acid, a polymer of D-glucuronic acid and N-acetyl-D-glucosamine. In the presence of N-acetyl-D-glucosamine, Candida Albicans shifts from its budding phase to the germ tube morphic shape shown above, consistent with the structures described by individuals with eye floaters!
See Castilla et al. http://www.ncbi.nlm.nih.gov/pubmed/9884022
Eye floaters are experienced by otherwise healthy individuals without the usual suite of expected markers of systemic candidiasis. What is going on?
- Re: Minimalist Yeast Abatement Proto... #147951
12 y
19,550
This is a reply to # 1,961,901The mobility of Candida Albicans in terms of morphic shifting between budding to hyphal and back to budding in response to temperature, pH, nutrient depletion, antifungal attack, immune system challenge, and biochemical changes to its environment has been well studied. This means that it certainly has access to other nutrient-rich areas in the body that suit its colonization requirements. The "eye floater" phenomenon suggests that the yeast has availed itself of this ability. But at the same time it must have techniques for coordinating and self-limiting its own proliferation in multiple colonization sites so as not to overwhelm its host.
Although the interaction of Candida Albicans with its host's metabolism is quite complex, the evidence that we have been examining here implies that acetaldehyde is not just a problem but THE problem in the case of an astonishing variety of disease states. Furthermore, assuming that self-limiting polysystemic colonization is indeed the case, then we can look for acetaldehyde-related connections to symptoms outside of the usual gastrointestinal locale, perhaps at the blood-brain barrier, for example.
Since the source of this toxic substance is now known to be a fungus (the yeast Candida Albicans), then why not just take a course of potent antifungals and be rid of it? There are certainly life-threatening infectious situations in immunosuppressed patients where an antifungal drug such as amphotericin B or fluconazole is imperative. However, the mode of action of antifungal drugs seeks to selectively eliminate fungal cells without targeting human cells and herein lies a problem. Both fungal and mammalian cells are eukaryotes (having a nucleus) and share more similarities at the molecular level than say human cells and bacterial cells that are prokaryotes (without a nucleus). This mean that the side effects from antifungal drugs may be almost as devastating to the host cells as they are to the yeast cells that need to be eliminated.
If we have learned anything from the indiscriminate use of Antibiotics over the past decades, it should be that the organisms that we seek to destroy in this manner do not succumb passively to these threats to their existence. The appearance of antibiotic-resistant bacterial strains attests to this. A guns-blazing approach to attempt to rid everybody of Candida Albicans will surely only result in the development of more antifungal-resistant strains.
Candida Albicans has entrenched itself in the human host. It can camouflage its cellular surface with receptors that make it look more like self rather than non-self to the immune system.
See Gilmore et al. http://jid.oxfordjournals.org/content/157/1/38.short
It has several different morphic states that it can use to avoid extermination. As a biofilm it can cover itself with drug resistant slime. In its hyphal state it is mobile and can seek out new more suitable locales by burrowing through tissue. As a budding yeast, its toxic byproduct, acetaldehyde, blunts the immune response to its presence, possibly by throttling the action of the thyroid.
See Acetaldehyde + thyroid //www.curezone.org/forums/fm.asp?i=1955669
Leave one yeast cell capable of budding and it can re-establish its colonization all over again.
Instead of trying to eliminate it, something that verges upon impossibility, strategies need to be employed that reduce it to a relatively benign commensal that no longer poses a threat to health. This must be accomplished using techniques that are powerful enough to have a significant impact yet gentle enough that they can be continued indefinitely.
First and foremost, the acetaldehyde that it releases must be neutralized. Although they didn't know at the time how it was working, the ad hoc clinical trial of Wondro (sulfurated flax oil) in the early 1900's demonstrated that this step, in and of itself, produces remarkable results. And this can be done by simply intercepting this toxic substance as a yeast waste byproduct in the throat and the gut before it encounters human tissue -- something that is non-provocative from the perspective of a yeast cell.
See Wondro for one //www.curezone.org/forums/fm.asp?i=1960885
See Proposed Wondro alternative //www.curezone.org/forums/fm.asp?i=1947895
In tandem with acetaldehyde scavenging the long-term production of acetaldehyde at its source needs to be reduced. But this is trickier because any direct assault on the yeast cells themselves may provoke avoidance reactions such as a budding to hyphal morphic shift.
Candida Albicans has acquired a sufficient arsenal of assault and avoidance techniques (acetaldehyde, phospholipase, biofilm slime, polymorphism) that should make it far more rapidly and fatally virulent than it actually is. Although its presence in everyone has long been known, instead of being identified as the cause of chronic conditions, it has managed to remain beneath the clinical radar, being relegated to a consequence of disease rather than an instigator. Why?
As a fungus it is totally dependent upon its host for its own livelihood. This implies that it must have evolved self-limiting techniques that allow for the continued existence of both itself and its host, even if the conditions that it precipitates through acetaldehyde excretion are potentially debilitating.
See White et al. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0030184
If so, perhaps we can tap into these very same techniques to facilitate a gradual (non-drug) approach to reducing its colonization in addition to scavenging its toxic byproduct acetaldehyde.
- Re: Minimalist Yeast Abatement Proto... #147951
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This is a reply to # 1,962,320If Candida Albicans can at one and the same time colonize multiple nutrient-rich sites in the body and self-limit its own proliferation, then it must have a technique for remotely sensing its own activity levels in order to coordinate this balancing act.
Quorum sensing is a stimulus and response system based upon population density, observed in bacteria and social insects, to regulate behavior via gene expression. Although the models studied to date have involved signaling molecules at the biochemical level to achieve this, there may be more to quorum sensing on the energetic level as well.
A striking example of this was provided by a simple experiment performed in a university biology lab as a cooperative student study project. Candida Albicans was grown on two identical culture dishes, covered and placed side by side in a temperature-controlled chamber. Identical culture dishes were placed on top of each of the experimental dishes. One was empty and the other contained several pellets of homeopathic sulfur.
Homeopathic sulfur is a substance produced by successive dilution of the original element over and over again until there is very little, if any, of the original substance left. But it is thought that the energetic signal of the original substance remains and is enhanced by the dilution process.
The yeast grown under the culture dish containing the homeopathic sulfur had a statistically higher incidence of hyphal growth as compared to the yeast grown under the empty culture dish which was more of the budding form. Apparently, Candida Albicans had "heard" the homeopathic sulfur signal and responded accordingly. It did not like the environment where sulfur, as heralded by its energetic signal, was assumed to be present. It shifted its morphology from budding to hyphal accordingly and was preparing to seek out better environs. There was no physical contact with the homeopathic pellets.
It is nothing less than amazing that the morphic form of an active yeast culture could be influenced by non-physical contact with a substance not only in a separate culture dish but also a homeopathic remedy as well! But isn't this something that the homeopathic practitioners have been telling us all along -- that they are able to manipulate metabolic biochemical processes using diluted substances conveying messages at the energetic level?
This particular remedy, sulfur, is indicated in a wide variety of conditions. The implications here are: 1) homeopathic sulfur may be shifting the morphology of the the yeast load in vivo away from the budding yeast form which carries out the acetaldehyde-generating fermentation process, and 2) that many of the various conditions for which homeopathic sulfur are effective may be a downstream result of the production of acetaldehyde from active budding yeast. When the yeast load within an individual is induced to stop producing acetaldehyde, the prognosis improves.
This meshes seamlessly with similar results obtained from acetaldehyde scavengers such as Wondro and antifungals such as garlic where a variety of diverse disease conditions respond favorably when acetaldehyde is removed from the picture, either by scavenging or by shutting down its production.
But what does this mean for quorum sensing? It implies that Candida Albicans may be able to remotely sense its own population and activity (hyphal versus budding, for example) at various colonization locales independent of physical molecular contact between the various sites where it has entrenched itself. If there is high acetaldehyde production at one locale, for instance, then this may automatically down-regulate acetaldehyde production at other locales. In this manner Candida Albicans could self-regulate its own virulence in order to rein in its ability to dispose of its host.
- Re: Minimalist Yeast Abatement Proto... #147951
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This is a reply to # 1,962,569The hints at polysystemic colonization provided by "eye floaters",
See //www.curezone.org/forums/fm.asp?i=1961901
and the suite of invasive and self-protective options (including quorum sensing) available to Candida Albicans,
See //www.curezone.org/forums/fm.asp?i=1962320
both suggest that the abilities of this organism to maintain its presence in the human host have been underestimated. We need to be at least as subtle and strategically-minded as evolution has made it in order to reduce its impact.
Although its major presence is in the alimentary canal from throat to anus and in female genital areas, it is important to realize that it may also have established sub-colonies in other nutrient-rich zones, such as the blood-brain barrier. Sustenance in the form of glucose, vitamins and minerals is supplied here in an endless stream on this pathway to the brain for any organism that can persist there.
Yeast may be able to maintain its presence below the clinical radar but it does leave detectable footprints wherever it may be:
• red rash on the back of the neck (possibly phospholipase irritation of tissue)
• scrunching sound during neck motion (possibly acetaldehyde modification of disulfide bonds in neck cartilage affecting elasticity parameters)
See //www.curezone.org/forums/fm.asp?i=1958887
• concentration problems/memory loss/brain fog (possibly acetaldehdye interference with choline acetyl transferase enzymatic processes)
See //www.curezone.org/forums/fm.asp?i=1949530
• "hangover" symptoms: headache, depression, anxiety, irritability (possibly acetaldehyde interference with brain biochemistry since acetaldehyde is also the breakdown byproduct of alcohol consumption and is able to cross the blood brain barrier)
See Heap L et al. http://www.ncbi.nlm.nih.gov/pubmed/7632171
• in severe cases, infectious processes in the brain (possibly acetaldehyde disruption of the tight junctions securing the blood-brain barrier )
See "leaky gut" //www.curezone.org/forums/fm.asp?i=1956265
And "leaky throat" //www.curezone.org/forums/fm.asp?i=1960577
The presence of yeast at the blood-brain barrier and its ability to quorum sense its own activity level may play a role in side effects experienced when the primary colonies in the alimentary canal are challenged. The sudden introduction of antifungals (such as garlic) into the diet can trigger what has been considered to be a "die-off" reaction (headaches, nausea, vomiting, etc.). While the Herxheimer reaction may indeed be a partial explanation of what is happening here, there may be other aspects to the problem.
By challenging the yeast in the gut outright with a potent antifungal, its budding activity there may decrease significantly. However, given that polysystemic colonization is highly likely, and that yeast may be able to quorum sense its own activity in various parts of the body, then the reduction of budding activity (and acetaldehyde production) in the gut may result in a commensurate increase of similar activity in the blood-brain region. Many of the "die-off" side effects are strikingly similar to brain exposure to acetaldehyde!
From a yeast perspective, this gives it "host-control" leverage. If the host ingests something that challenges it in the gut, it can "punish" the host with more severe brain-active symptoms with the likely effect that its host will revert to previous behavior and remove the antifungal from its dietary intake. It already appears to be exerting host control suppression of the immune system response to its presence via acetaldehyde-mediated interference with the thyroid.
See //www.curezone.org/forums/fm.asp?i=1955669- Re: Minimalist Yeast Abatement Proto... #147951
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This is a reply to # 1,971,136Although much attention has been given to the role of heavy metals in the etiology of autism [1], there is considerable controversy and less than definitive results in this regard. Since there are cases of autism where there has been no detectable level of mercury exposure, either environmentally, through mercury fillings, or the vaccine preservative thiomersal [2]; this is used as an argument that mercury doesn't cause autism. However, enzymatic biochemical pathways that are linked to diseases aren't particular about what is interfering with them in relation to manifestations of the disorder, only that they have been inhibited or impaired. This means that mercury may be one of many causes of autism that block certain critical metabolic pathways that are essential to maintaining the mental alertness that is being compromised.
Since mercury does seem to trigger this condition in some individuals, we should be looking for other entities that are also onboard which might share its disruptive profile. Mercury is a heavy metal, a highly electrophilic positive cation that likes to bind to exposed sulfhydryl groups. It can easily drift into and damage cysteine residue enzymatic reaction pockets because of its miniscule size. This behavior can interfere with critical biochemical pathways by shutting down the enzymes responsible for maintaining them.
In a lineup of potential perpetrators, acetaldehyde (the pseudo heavy metal) also matches this profile:
See "Acetaldehyde -- Pseudo Heavy Metal" //www.curezone.org/forums/fm.asp?i=1953097
This is something that everybody is coping with in one way or another as a byproduct of yeast fermentation of carbohydrates with the dosage dependent upon yeast colonization levels. But if everyone has yeast and acetaldehyde can cause autism, then why doesn't everyone have it?
This is where the genetic predisposition comes in. Symptoms from chronic acetaldehyde exposure don't manifest until dosage levels and damage approach disease thresholds. Then each individual begins to display a "known" disease based upon the weakest link in their unique genetic profile. Monozygotic twins are much more likely to develop similar autistic disorders than dizygotic twins [3].
So now we have at least two potential causative agents, mercury and acetaldehyde, sharing similar molecular profiles that may be responsible for the autistic suite of symptoms. What is worse is that they may have a synergistic deleterious effect when combined by competing for the resources in the body designed to deal with this type of toxicity. The body has a natural heavy metal chelator in the form of the protein metallothionein [4].
If an individual is fortunate enough to have low background yeast levels, then they may be able to cope with mercury exposure within reasonable limits without showing any adverse effects -- these are the children who get vaccinated (even with thiomersal-preserved products) and are just fine. However, if an individual has a high background yeast level with acetaldehyde emissions that are saturating their metallothionein competence [5], then any incremental exposure to mercury will set off a cascade of negative consequences, possibly including the autism reported subsequent to vaccinations if they are genetically predisposed to this condition.
The thionein apoprotein of metallothionein has an abundance of sulfhydryl cysteine residues that function as snares for the reactive oxygen species and toxic metals that can bind to them. Sulfur loci available for binding are also prominent in the proposed structure and mode of action of Wondro:
See "Wondro" //www.curezone.org/forums/fm.asp?i=1944518
See "Wondro Mode of Action" //www.curezone.org/forums/fm.asp?i=1944969
Metallothionein is something that the body has to make via protein synthesis from amino acids with a dependence upon dietary cysteine (or methionine). But we have already explored what excess acetaldehyde can do to the body's sulfur-based metabolism:
See "Cysteine + Acetaldehyde" //www.curezone.org/forums/fm.asp?i=1973900
See "Methionine + Acetaldehyde" //www.curezone.org/forums/fm.asp?i=1977201
In other words, functional metallothionein may be in short supply because of limited cysteine availability, something that has also been described in relation to autism [6]. As well, the molecules of this precious protein that there are may be just barely coping with daily levels of acetaldehyde exposure. This is a recipe for disaster when even the minutest levels of mercury are incrementally added to the mixture. A exposure dosage that would normally be tolerated cannot be scavenged by the under-produced and overloaded metallothionein protective mechanism and spills its toxic presence into critical enzymatic interference.
If this trauma concomitantly compromises the immune system's back-pressure on current yeast loads because of neutrophil impairment by mercury [7], then the yeast population may ratchet higher to another tolerance level with a higher daily dosage of acetaldehyde release. Subsequently, even after any detectable levels of mercury have been eliminated [8], the autistic spectrum disorder may persist because of the increased acetaldehyde levels. Mercury (the actual heavy metal), which was the initial trigger of the symptoms may have waned but acetaldehyde (the pseudo heavy metal) remains a daily occurrence.
Disruption of serotonin metabolism is common in autism [9] and the monoamine oxidase pathway that regulates the concentration of this neurotransmitter is exquisitely sensitive to acetaldehyde and its metabolites:
See "Serotonin Catabolism + Acetaldehyde" //www.curezone.org/forums/fm.asp?i=1972530
If the heavy-metal mimicking effects of acetaldehyde are a major factor in the etiology of autism, then we should find situations where autism appears because of treatments that result in higher yeast loads, even in the absence of overt mercury contamination. One such commonality is the prevalence of autism in conjunction with Antibiotic treatment for otitis media [10].
See "Ear Infections + Acetaldehyde" //www.curezone.org/forums/fm.asp?i=1971424
If autism is a genetically modulated disorder related to interference with enzymatic sulfhydryl metabolism, precipitated by mercury (via either dental Amalgam or thiomersal) and/or yeast-released acetaldehyde exposure, then together with ensuring that mercury contamination is no longer an issue, the treatment focus should be shifted to acetaldehyde scavenging and yeast abatement so that the crucial impacted metabolic pathways may resume normal function.
[1] Desoto Master-Cleanse et al., "Sorting out the spinning of autism: heavy metals and the question of incidence.", Acta Neurobiol Exp (Wars). 2010;70(2):165-76.
http://www.ncbi.nlm.nih.gov/pubmed/20628440
[2] Blaxill MF et al., "Thimerosal and autism? A plausible hypothesis that should not be dismissed.", Med Hypotheses. 2004;62(5):788-94.
http://www.ncbi.nlm.nih.gov/pubmed/15082108
[3] Bailey A et al., "Autism as a strongly genetic disorder: evidence from a British twin study.", Pschol Med. 1995 Jan;25(1):63-77.
http://www.ncbi.nlm.nih.gov/pubmed/7792363
[4] Coyle P et al., "Metallothionein: the multipurpose protein.", Cell Mol Life Sci. 2002 Apr;59(4):627-47.
http://www.ncbi.nlm.nih.gov/pubmed/12022471
[5] Hao Q et al., "Aldehydes release zinc from proteins. A pathway from oxidative stress/lipid peroxidation to cellular functions of zinc.", FEBS J. 2006 Sep;273(18):4300-10. Epub 2006 Aug 23.
http://www.ncbi.nlm.nih.gov/pubmed/16930132
[6] Suh JH et al., "Altered Sulfur Amino Acid Metabolism In Immune Cells of Children Diagnosed With Autism", Science Publications (2008).
http://en.scientificcommons.org/46275754
[7] Worth RG et al., "Mercury inhibition of neutrophil activity: evidence of aberrant cellular signalling and incoherent cellular metabolism.", Scan J Immunol. 2001 Jan;53(1):49-55.
http://www.ncbi.nlm.nih.gov/pubmed/11169206
[8] Ip P et al., "Mercury exposure in children with autistic spectrum disorder: case-control study.", J Child Neurol. 2004 Jun;19(6):431-4.
http://www.ncbi.nlm.nih.gov/pubmed/15446391
[9] Burgess NK et al., "Hyperserotoninemia and altered immunity in autism.", J Autism Dev Disord. 2006 Jul;36(5):697-704.
http://www.ncbi.nlm.nih.gov/pubmed/16614791
[10] Fallon J, "Could one of the most widely prescribed Antibiotics amoxicillin/clavulanate "augmentin" be a risk factor for autism?", Med Hypotheses. 2005;64(2):312-5.
http://www.ncbi.nlm.nih.gov/pubmed/15607562
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