Re: Detoxifying acetaldahyde (Candida & Dysbiosis Forum) 6/26/2012 1956532

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Re: Detoxifying acetaldahyde

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Re: Detoxifying acetaldahyde

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Acetaldehyde inhibits the enzyme protein tyrosine phosphatase (PTP), possibly by blocking the conserved cysteine (sulfur-containing) residue at the active site. PTPs are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. The unimpeded action of PTPs are a necessary part of the formation/maintenance of epithelial tight junctions. These tight junction structures seal the intestinal walls so that they are impermeable to macromolecules and fluids.

Translation: "acetaldehyde can punch holes in the intestinal wall = leaky gut syndrome"

See Atkinson KJ, Rao RK, http://ajpgi.physiology.org/content/280/6/G1280.full

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