I have read that when you start doing the gall bladder/liver cleanse, that it takes 6 to 8 flushes - doing one every two weeks. After that, doing a cleanse once every six months. I have finished 6 flushes. I have not experienced problems during the flushes. I have only experienced relief from some miserable symptoms. Before doing the cleanses I used to become nauseated and experience terrible indigestion after eating fatty foods. I also had food allergies - and was breaking out in spots on my arms. I also experienced alot of muscle pains. All of these symptoms are now either gone or very slight. From personal experience, I would recommend trying the flush............I have only had positive results.