The familial relation may be more likely to be associated environmental conditions. Toxins, diet patterns, life style choices within the group.(genetic disposition while becoming conventional and popular, doesnt sync with the increasing knowledge of how DNA, RNA and genes exist and change. Cancer's gene driven factor theory has been destroyed by Dr Seyfrieds study.)
Id say the hyperbaric chamber treatments are the best first part of the whole protocol, for the level of severity. They are readily available and can even be rented.
see Dr Tennant: https://vimeo.com/106257471
Dr Tennant describes a number of disease reversals, from candida, serious brain fog to debilitating diseases like you describe . One: an accident caused comatose situation being completely relieved in a matter of days, after attending physicians had advised disconnection of life support, by discerning the areas of low voltage and infusing voltage continuously(days) with skin patches placed at points feeding the brain with Tennant's Biomodulator device. His Scenar influenced, voltage reading and infusing, device.
So hooking up the voltage infuser device of choice and economic availability, to the patient, w multiple patches at appropriate sites for infusing the meridians and muscle fascia with electrons.
With your serious description the main circuit could be fed by connecting the regular torso points, front and back, with the inexpensive zapper. (one caveat of necessary assisting treatments would also be healthy diet, necessary raw materials, elements and minerals, detoxing threrapies ect)
Don't forget the power of the hidden dental infections role in disease!!!