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Re: This study proves my point! (edit)

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Michael B Views: 3,630
Published: 12 years ago
This is a reply to # 1,850,332

Re: This study proves my point! (edit)

Some call it denial. For you though, it is obviously ignorance.

Here's your study, mercury brain:

"ALA has been shown to affect the release

of glutathione into bile secretions. In animal studies,

increasing amounts of glutathione in bile has

been shown to dramatically increase the release

of inorganic mercury. ALA given intravenously

to rats at doses of 37.5-300 μM/kg was shown to

increase inorganic mercury release in bile by

1,200-4,000 percent immediately after mercury

exposure.67 Levels of released inorganic mercury

remained at a 300-700 percent elevation, even

three hours after dosing with ALA. If mercury was

injected 24 hours prior to the administration of

ALA, the increase in release of inorganic mercury

was substantially less, but was still elevated 140-

330 percent. A lower dose of ALA (37.5 μM/kg)

was more effective than higher doses at increasing

the biliary elimination of methylmercury.

There was disconcerting evidence from

this study, however, that ALA may also alter the

tissue distribution of mercury and other heavy


Although levels of inorganic mercury and

methylmercury in the kidney dropped significantly,

levels of inorganic mercury also increased

significantly in the brain, lung, heart, and liver tissue.

Methylmercury levels had also increased in

the brain, intestine and muscle of the rats given

ALA. The same phenomenon occurred in rats exposed

to cadmium and given the same doses of

ALA. Levels of cadmium in the liver dropped

(where cadmium is most frequently stored) but

increased in the kidney and muscle. The same was

true in rats given copper and ALA; all tissues examined

had increased levels of copper, except for

the liver (where copper usually accumulates)

where levels had dropped.67 In all cases the pattern

was the same; the tissues that concentrated

the metal (blood, spleen, and kidneys in the case

of methylmercury) had reduced concentrations,

while other tissues appeared to have a greater concentration."

Here is a patient report from

As for your second question, you were obviously proven ignorant. read my response again:

-You obviously got excited because you read some study about the half life of ALA. And of course, without doing ANY THINKING OR REASONING on your part, you blindly assumed cutler was wrong and you were right. What you DON'T know is that ALA is quickly converted by the body to DHLA. It is the DHLA that does the chelating and has the half life of 3 hours.

As for your third question, I already pointed out to you that an administration of dmsa once every six or 7 hours is not considered "infrequent" because the blood still has dmsa in it. It is simply not the ideal frequency, and redistribution will happen although less than with an infrequent dose of say, once per day. Dosing at the half life is a very well known practice in pharmocology and you seem to thinkt that you are on to something by bashing anyone who draws the same conclusions that andy cutler does.

Yep, feel that lump in your throat? Swallow it down. You are proven wrong. Have fun pretending to know anything!

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