I agree that knowing the mechanisms is important and I likewise agree that there is reason for caution when supplementing with very large amounts of vitamin D3. However, MY POINT is that when one does not get vitamin D from natural sunshine or perhaps fish oil, in the vast majority of people they would be far better off to use supplemental vitamin D3 than to allow themselves to become vitamin D deficient. To say otherwise is advice that is not only wrong, but potentially harmful for most people.
I will also point out that, vitamin D3 is indeed produced via a chemical process, the process alters lanolin from sheep's wool into vitamin D3. To me, while not preferable in any way to natural vitamin D3, that hardly sounds as Franensteinish as other lab created compounds.