Disrupting natural sleep-wake rhythms causes behaviour, metabolic changes

(NaturalNews) Could allowing our lifestyles to disrupt the natural 24 hour rhythm of our bodies affect our behaviour? Researchers from The Rockefeller
University and the Mount Sinai School of Medicine in New York have found that disruption of natural circadian rhythms, as seen in shift work or
international travel, could be causing significant changes in our brains, bodies and behaviours.

A study published January 25, 2011, in the journal of the Proceedings of the National Academy of Sciences (PNAS), titled "Disruption of circadian clocks
has ramifications for metabolism, brain, and behaviour", examined the effects of making subtle changes to the sleep-wake cycles of mice. The mice were
placed in a 20 hour light-dark cycle, rather than the normal 24 hour cycle, for 10 weeks. Significant effects were found in the brains and behaviour of the
mice.

The mice exhibited changes in metabolic hormones resulting in accelerated weight gain and obesity, as well as behavioral changes such as increased
impulsiveness and decreased mental flexibility. "In the brain, circadian-disrupted mice exhibit a loss of dendritic length and decreased complexity of
neurons in the prelimbic prefrontal cortex, a brain region important in executive function and emotional control. Disrupted animals show decreases in
cognitive flexibility and changes in emotionality consistent with the changes seen in neural architecture."

The Rockefeller and the Mount Sinai research team, led by neuroendocrinology post-doctorate Ilia Karatsoreos, is attempting to map out how environmental
disruptions of

sleep-wake cycles affect human biochemistry in terms of hormones, metabolism and the genes that drive our circadian rhythm. The work suggests that our
modern lifestyle could be significantly affecting us in ways not yet understood.

According to Karatsoreos, "The circadian system is a 'web,' with rhythms at the molecular level driving rhythms at the cellular level, which results in
rhythms at the tissue level. This can lead to a cascading set of effects throughout the whole organism, and we want to understand how exactly that
happens."

New York's Rockefeller University, established in 1901, is a centre for research and graduate education in the biomedical sciences, chemistry,
bioinformatics and physics. PNAS is one of the world's most-cited multidisciplinary scientific serials. Since its establishment in 1914, it publishes
leading research reports, commentaries, reviews, perspectives and colloquium papers.

[Editor`s Note: NaturalNews is strongly against the use of all forms of animal testing. We fully support implementation of humane medical experimentation
that promotes the health and wellbeing of all living creatures.]

SOURCES

About the author

Dave Gabriele, D.Ac, BA, is a registered acupuncturist, a practitioner of traditional Chinese medicine and a health researcher helping people in and around
the Greater Toronto Area. He is the founder of Life Balance Family Health Care ( www.balanceyourlife.ca), an organization committed to providing people with the information
and guidance they need to make positive lifestyle changes. Dave has been a teacher of Chinese martial
arts since 1997, including the arts of Taiji and Qigong.