Hi Paulette- According to ARL it depends on what stage of stress you are in. Just like Onedaysoon when I was in the 4 low pattern I was put on lots of calcium/magnesium. It wasn't until I was out of the 4 lows that I was given the B's which came in a multi that they added to my protocol. If you are in the 4 low pattern it would be a good idea to leave them out for now as they are quite stimulating. This may actually set you back in your healing.