Anxiety, depression, and more. I fee... 
Iwanttofeelok
11 y
8,966
† Cross †
Male, early 20s
My history:
Diagnosed celiac
Diagnosed autistic spectrum disorder (i tend not to agree with this diagnosis, but then again, I'm no neurologist), depression, and anxiety
I've dealt with Depression for a long time, and this is in part due to issues I've had with abusive stepparents, my family, my sexuality, and other things I guess.
Since starting college, I've abused drugs pretty regularly, but I've now stopped everything except nicotine and the occasional coffee.
I dont eat dairy or meat
My symptoms started about 4 months ago. They've gotten a bit better since, I think largely because of some supplements and dietary changes, but I still don't feel ok.
Symptoms include worse Depression and anxiety than I've ever experienced. I have frequent panic attacks during which I strongly believe that I am on the verge of either death or a psychotic break. Even when i am not having a panic attack, i experience general anxiety and some derealization/slight depersonalization.
Difficulty concentrating. I also have 'floaters' in my eye which exacerbates anxiety, derealization, and difficulty concentrating. My appetite isn't very strong. I sometimes get headaches. I feel very lightheaded sometimes, often needing to lie down. Stomach aches. I sometimes have trouble sleeping. I often feel better later at night than I do during the day.
I feel easily overwhelmed and often want to be alone, but then when I am alone, I wish I had company.
Acne was never much of a problem for me, but I've started breaking out, even on my chest. My tongue is often white, and brushing it only helps a bit. Besides mental cloudiness, i am also physically fatigued much more often than should be the case.
I don't like going outside anymore. Cloudy or rainy days make me feel worse, but I am also sensitive to bright sunlight.
I am sort of bloated. I'm not fat, but my abdomen seems to extend disproportionally to the rest of my body, I guess.
I'm not sure if this is anything abnormal, but I experience deja vu somehat often which always leaves me feeling scared.
I want to feel healthy, but I'm not sure that I even know what that means. More than anything, I just have the nagging feeling that something isn't right, but I guess that is probably just the anxiety.
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- Re: Anxiety, depression, and more. I... koifishgal
11 y
8,614
This is a reply to # 2,087,736Hey there! Depression is connected to a lot of factors, some of them are mentioned above. I was suffering from Depression as well, it started off as anxiety too. It went on for couple of months, then I started seeking help from alternative therapy consultants and I got introduced to Home Remedies. I made a lot of changes in my lifestyle and my food habits. I realised my food was adding fuel to fire. To make it more convenient, I recently downloaded this app called QuickCure for my iPhone. Here is a link http://bit.ly/13khXII
This app will help you with all your worries.
I have a few tips that may come handy for you. Start thinking positively, indulging in exercises & get busy with work. Don't compare your life to others, remember we all are unique. Depression feeds & grows on such thoughts. Meditation has helped me build a lot of confidence & strength. Give it some time & follow the app for any other ailments you will definitely see the changes in your life. Hope this helps.
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- Re: Anxiety, depression, and more. I... aijian
11 y
8,760
This is a reply to # 2,087,736You are hypersensitive to candida and your total load is too high. That's why you react to mold (rainy or cloudy days) and electromagnetic field (sun light). All you symptoms are due to various hypersensitivities. Avoid all allergens. Minimize exposure to UV light and fluorescent light. Avoid fluorescent light and strong lighting (computer screen).
When you feel better, you can starter killing your high candida load. Take coconut oil for this.
Étienne - Re: Anxiety, depression, and more. I... purplepixie
11 y
8,520
- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,388
This is a reply to # 2,087,949PurplePixie how do you feel about epigenetics and the possibility that those methylation cycle gene defects can be "fixed"? This is getting back to cause and effect. Just wondering your thoughts since you've done so much research on this.
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,575
This is a reply to # 2,087,959Hey Craig..I really don't know much about nutrigenics...just 1kb amongst the trillions of gigabytes!
Mainstream Science likes to tell us that our genes are fixed and unchangeable.
Other scientists like Bruce Lipton things otherwise and says gene expression changes all the time.
So the gene angle of health is an incoherent murky pond when it comes to knowing if we can in fact CHANGE gene expression.
As Nutrigenomics is such a new field of health recovery protocol, all we really have to go on is the clinical work done by others (like Yasko) and others who work similarly to her with primarily the methylation cycle.
The methylation cycle is considered the 'backbone of our physiology'...so focusing on those genes out of the hundreds of thousands of genes, makes the job manageable and aims healing at pathways which deal with toxicity which is known to cause health issues.
Her work with autistic children specifically has been ground-breaking and has achieved results with this route of gene testing and supplements to 'bypass' gene mutations to bring-about speech in those children, more constant moods and healthy interractions with others etc.
It is known when parents of autistic kids have tried every drug and doctor to no avail they go to Yasko, as she seems to be the only one to help symptoms lessen and improve their overall development than drug kids up on tranquilisers like rohipnol!
Yasko opened-up her experience with this to others with general health conditions as she realised that especially with the methylation pathways, affecting so many functions of the body - that many people could benefit from knowing the info and using the correct supplements to provide what the gene expression is not doing.
It's saved me loads on supplements...as before gene testing i was literally spending hundreds on supplements that did not help. I was even taking some (like NAC and milk thistle) that is terrible for someone with CBS gene problems as they are both high sulfur supps...putting extra burdon on that pathway which causes high cortisol.
The supps i take are directed at the specific mutations and i am making progress. It's like finally being able to take a full breath and feel i am getting somewhere...to finally have symptoms lessen. The info also helps me choose a diet better suited. Digestion is much better.
I would highly recommend it for someone with chronic health problems that the normal full body cleansing route hasn't helped.
Pheonix rising forum have member who primarily has Chronic-Fatigue-Syndrome and similar conditions using nutrigenics and many on there are exploring the benefits of bypassing mutated genes.
It's not a quick fix route...afterall it's about (detox) pathways which are not working well and opening them up to work well caused all those stored metals and toxins etc to be released suddenly so it's vital to go slow.
1mg of methylfolate has me seriously herxing still.
I am patient after years of trying so many routes...but i personally plan to retest the genes after a prolonged period on this protocol and (hopefully!) continued improvement of symptoms, to see if in fact my gene expression has changed. This is afterall the big question i've been pondering and personally can test in the near future.
Unfortunately even Yasko thinks that genes don't change so she doesn't re-test her patients after remission of symptoms.
It's such a new field of health healing that fingers crossed, as more people get on board, we will within even 3 years know 50 times as much as we do now.
Of course, all the other healing modalities are vital to health and i'm not saying ditch all of those and just focus on genes. If i didn't have my quiet meditation time, or say 'no' to the busy life others want me to have, i know i wouldn't be healing aswell as i am. It's important to try a multi-focused approach to health.
Genes being our (changeable?) 'blueprint' determine so many body functions that it is an exciting prospect to include that too - it's really helped me make significant improvements.
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- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,542
This is a reply to # 2,087,971Thanks for that.
You said she (Yasko) doesn't think that genes change. I assume you mean not just the sequencing but the actual changes and expressions of each gene as well? I'm hoping she is wrong about that. With that said, this is definitely a direction I would focus on more if what I'm doing doesn't end up working.
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,526
This is a reply to # 2,087,992Yasko says the gene sequence doesn't change but gene expression is changeable (from her book Autism: pathways to recovery):
http://www.dramyyasko.com/resources/autism-pathways-to-recovery/chapter-2/:
"DNA Silencing
Methylation is critical to what we call “gene expression.” Although your genes never change, they can be active or inactive, as we saw earlier in this chapter. The body turns on (expresses) a gene, or turns off (silences) a gene. Whether it’s preferable for the body to either express or silence a gene depends on its role.
How does this work? To regulate our DNA, to help to turn it on and off, the body adds methyl groups to the DNA strands. If you think of your DNA as a charm bracelet, it’s as if the methyl groups are hanging off the bracelet at different points. Wherever there is a methyl group on the bracelet, those genes will be silent, and wherever the methyl group is removed, those genes will be expressed. A lack of proper methylation means that DNA that should be quiet can be expressed, and this may cause specific changes in the body. For example, many children change hair color as they grow older. A child with blonde hair may change into a brunette. This is because the gene for brown hair, which was switched off, becomes switched on. Lactose intolerance is another example. You may be able to easily digest milk as a child, but once your gene for lactase, the enzyme for digesting milk, is switched off, you no longer can.
Of course, gene expression or silencing can have far more significant consequences than hair color or lactose intolerance. Take the measles, mumps, and rubella (MMR) vaccine as an example. When viruses (such as those contained in this vaccine) are inserted into your genome, it’s not healthy for those viruses to be “turned on” and become active. However, without adequate methylation, that’s exactly what can happen. Unless you have adequate methyl groups that attach themselves to the viruses to silence them, they can become active."
Like i said Craig - i plan to re-test these significant genes once i've been on this protocol for 18-24 months and evaluate any gene changes on any level.
It's a route i would recommend to complement any other health regimen. It does take a bit of 'head' work to figure it out oneself without a practitioner, but as information on the net grows, it'll be easier for everyone to bypass expenses of a practitioner. If i had the money i would use a practitioner. Brain fog and learning nutrigenomics isn't a match made in heaven ;-) But if i can do it, anyone else can, if they make the time to learn.
- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,618
This is a reply to # 2,087,995I think I understand better now. Yasko says that the body can manipulate gene expression through methylation but she doesn't think it is possible for Science to do it currently so she works around it with supplements and such and doesn't bother retesting.
I believe the methylation that is causing negative symptoms is not an error but is being signaled for. I believe this signal can be stopped. Time will tell. Thanks for persisting through the brain fog to bring us knowledge!- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,467
This is a reply to # 2,088,006I think i see your point of view craig - certainly we have to ask the BIG question what TRULY makes the genes express.
From Yasko's perspective methylation helps to SILENT genes...so if a person has MTHFR and is under-methylating then many genes are being expressed for all kinds of diseases and symptoms.
Methyl donors help to control expression of genes. Turn them on or off...rather allowing all genes to be expressed. Essentially methyl donors act as a master controller of genes.
I do wonder why any element of our physiology, whether that be physical, emotional, spiritual - would 'switch-off' methylation and allow the gene expression to 'run amok'.
If the PRIMARY role of every element of us is for 'survival' (of our individual selves: the species as a whole) why would an organism on any level, choose to genetically 'self-destruct'?
I ponder this often. I am open-minded about all of this and haven't reached any firm conclusions. The only reason i can think of when 'self destruct' occurs in the case of genetics, is where the gene-pool has become so 'tainted' that it is a part of 'survival of the fittest' occuring - that organism should not survive for it's gene-sequencing is becoming so tainted with mutations that procreation would cause even worse results and in the long-term, would eventually cause a die-off of the entire species.
We see now in modern society an epidemic of diseases...happening to people younger than previous generations.
We have an ever increasing terminology for these diseased-states we see so often now which were near non-existent in the 50's for example.
I wonder if genetically we are becoming weaker and weaker as a species.
However, i read that scientists have possibly found a function for 'junk dna' and that it is the element of our 'higher brain' at work...the parts associated with being able to communicate beyond the known common senses, telepathy etc.
I will post the link if i can find it later on but they went on to suggest that this DNA is sensitive to frequencies and can be altered through specific frequency codes. The article went on to say that is perhaps what language first was originally meant for...a collection of sounds (frequencies) to program our DNA.
So while physically trying to help alleviate gene mutations with supplements and nutrition is a valid route and brings relief, i do believe that there is a technology far more advanced, and still yet to be fully understood, that is able to 're-code' us back to a more 'purer gene blue-print' and enable survival of the species.
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,420
This is a reply to # 2,088,200Here is the link to the article about the scientists discovering frequency healing of 'junk' DNA:
http://www.mindopenerz.com/scientist-prove-dna-can-be-reprogrammed-by-words-a...
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,420
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,467
- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,618
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,526
- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,542
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,575
- Re: Anxiety, depression, and more. I... Craig1129
11 y
8,388
- Re: Anxiety, depression, and more. I... purplepixie
11 y
9,024
This is a reply to # 2,087,736Hi there,
I'm sorry you're feeling the way you do - i know the anxiety, depression, derealisation experience so well too and really do empathise with you.
You say you've been diagnosed autistic...have celiac too...and i can't help but mention the methylation cycle genetic defect possibility to you as it's something i've had tested and shown positive for many defects in the cycle which affects HCL acid secretion, neurotransmitter formation and breakdown, turning genes on and off, detoxing, ability to detox metals...many many vital functions of the body are screwed-up when methylation is out of whack - and the concequence of such mutations leads to too many numerous conditions to list here, but suffice to say range from psychological symptoms all the way through to full blown physical, neurological impairment.
The good news is that you are young and seeking answers. Keep on that trail - you know something isn't right despite adjusting diet, toxic load etc so follow that rabbit down the hole :-)
Dr Amy Yasko specifically works with autistic children and has found 100% of those she treats has mathylation cycle genetic mutations - specifically MTHFR (a gene and enzyme), COMT, CBS, MTR, MTRR - these are all genes i nthe methylation cycle that do really important things.
Ben Lynch also works in this area and has his own site :
http://www.mthfr.net
Of course you can go the long way round and find out you have excess histamine, homocysteine, not enough serotonin, gaba, and overload of nitric oxide , glutamate etc etc through seperate tests costing thousands - but through genetic testing you will be able to see which genes are altering the amount of these things in your body giving such symptoms as you describe.
Or like me you could spend years detoxing various parts of the body and get no-where when you read everyone else feels fab from doing it! Methylation problems leads primarily to all toxins in the body being stored and not naturally detoxed so when someone with MTHFR does a Water Fast they stir up toxins and don't excrete them like normal folk...hence feeling worse despite diligently fasting/detoxing.
If you have funds go through ben lynch, Yasko or another practitioner to guide you on a supplemental journey to bypass any gene mutations.
Or if funds are low go to 23andme.com and order a kit for 99 bucks - but you'll have to do loads of research to understand the mutations yourself - aswell as how to treat them. (im going to ask mods here to start a forum for this so we can help each other more in this subject)
Of course aside from genetics as another poster mentioned candida, baceria, viruses, parasites could be playing a part in your condition and it's wise to avoid a crappy diet which feeds such things and try to clean-up your diet. Dr Yasko has found that when doing her protocol for gene mutations that viruses and parasites, metals etc get excreted once the detox pathways are working better and the immune system gets stronger. She has found that viruses get excreted along with metals specifically in her clinical experience.
I would suggest the fail-safe diet - google it - it's a diet that cuts out all additives, amines (glutamine, histamine)...MSG and the like. If you have allergies it's an ideal start as many foods raise histamine which also raises your allergic response.
For years i have tried many routes to find 'cures' to what ails me including detoxing, cleansing, most of the alternative healing arts such as meditation, reiki, shiatsu, crystals, EFT, EMDR, CBT, swallowed a libraries worth of 'positive thinking self help books, switched to many 'pure' diets such a raw vegan, cooked vegan, raw fruitarian, liquid diets, always vegetarian (never could tolerate flesh foods of any kind, severe constipation), the list is endless to the work i have done to 'clean up' my life, body, mind, and diet in order to find health.
None of the above worked for me, they just made me momentarily feel 'ok' while doing them - no lasting effects and certainly no change to symptoms in the long run. Nothing worked until i did the gene test, and started on a protocol aimed at bypassing or helping the genes not working well.
An upregulated CBS gene for example can lead to adrenal insufficiency as it produces huge amounts of ammonia and alpha-ketpbutyrate which chronically raises cortisol - ultimately leading to depletion of many hormones and neurotransmitters as the body will prioritise cortisol production over any other hormone. An upregulated CBS gene works 10 times as fast as normal. So the demand for cortisol is 10 times as much as normal. Which of course leads to adrenal fatigue. There is no way it couldn't.
I have 4 upregulated CBS genes and restricting sulfur foods has helped take the pressure off the adrenals.
When my dogs bark i no longer have an anxiety attack!
Have you tested your BP? High histamine and nitric oxide are vasodilators and could easily be causing your light-headed weak feeling. I have this and test my BP regularly...it's averaging around 80/50 with a BPM of 90. My veins bulge. I'm really trying hard to control histamine and am just starting a new protocol to address this more aggressively to help raise my BP.
Low BP with cause a HPA axis stimulation as the heart has to work harder to pump blood around the body...so the heart rate speeds up which triggers anxiety and the ANS (autonomic nervous system) and the HPA axis....which throws out adrenaline and cortisol to raise BP...leading a person into a loop of HPA activation, anxiety, and eventually total depletion. Talk therapy won't touch the sides of anxiety if the route cause is low BP due to excessive amounts of vasodilating chemicals in the body.
Also the gene GAD converts glutamate to gaba, which is mutated leads to excess glutamate, which causes brain excitotoxicity, racing mind, anxiety etc...many pubmed studies show the link between GAD gene and anxiety....i think that's why mainstream medicine call anxiety syndrome General Anxiety Disorder (GAD for short) as they know impairments in this gene produce anxiety due to excess glutamate. Excess glutamate is prolific in autistic children.
I have 5 GAD genes +/+ mutations (full mutation) and I take GABA which helps to calm me somewhat...Phenibut form of GABA goes direct through the blood brain barrier (BBB), whereas taking just GABA takes a few weeks to build up in the system. Phenibut is not good to take everyday long term (i don't). GABA is okay longterm. I shall switch to GABA when phenibut runs out. I use phenibut on 'really bad anxious days', 250mg works okay...to function, 500mg tranquilises me and i have to lay down so be careful with dosage.
Phenibut/GABA has helped me not become completely 100% agoraphobic and suicidal. It's a life-saver for extreme anxiety.
I hope some of this info is of some help, sorry for the long post, go with your instincts as you know your body best. I have detailed some things which may or may not be an issue for you, investigate more and don't give up...CZ is a great place for piecing together this 'healing puzzle' we've all been dealt with.
My best wishes to you on your healing journey..big hug.
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,478
This is a reply to # 2,087,955Thanks a lot for your post. You're obviously very knowledgable.
I simply don't have the funds to spend $100 at the moment (poor college student) but once my financial aid comes in, I am planning on seeing a naturopath. Do you think they will be able to help me with the gene testing?
Assuming that I do have a MTHFR mutation, are there ways to treat this through diet without buying expensive supplements, at least until I can afford confirmation through genetic testing?- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,859
This is a reply to # 2,088,033There are very few naturopaths doing gene testing - look online for any nearest to you.
A general naturopath will more than likely have you do a plethora of different tests, saliva hormones etc which will cost a lot, extra money too for their supplements. It's still a valid route to go down but in reality the protocol many suggest are ones which are available online to anyone - eat well...cut out refined foods, sugars, caffeine, alcohol etc..more veggies and fruits...etc etc...take a good multi supp.(that you cant be sure you necessarily need), take some herbs (which you could easily react to) ...It's a blind alley to start pouring vits and herbs into yourself if you don't know without spending hundreds on tests - if you need them.
With funds being tight at the moment it is best to do an elimination protocol....really strip down the diet (fail-safe diet as suggested above)...this will determine which foods are potentially causing you trouble without you being aware.
To be honest a fully stripped-down diet is not nutritionally complete so only be on it for a week and slowly introduce food groups, like dairy...sulfur veg, gluten etc...see which foods you react to. Keep a journal to keep track of where you're at...helps to look back on it to see when symptoms occurred and with which foods.
Try to cut out caffeine for a while...i know it's a bind as caffeine is one stimulant the world is addicted to, understandably, but i had a friend with coeliac who was allergic to the very tiny amount of oil found in fresh ground coffee beans. They would rather be on medication for bad peristalsis and gut dysbiosis for life than give up coffee amazingly!
Stop any supplements and then try vit C to start...1g a day...see how you react. Add magnesium (malate, citrate NOT oxide)...that's excellent for health in general coupled with vit C. These are the cheaper supplements yet the most worthwhile.
I really would recommend GABA when funds allow for your anxiety. There are numerous herbs and other supps for anxiety, and i've tried a huge handful of the better known ones which didn't do squat for my anxiety...GABA is the brain's 'calming' neurotransmitter. Only thing that actually did what it's known to do for me.
When funds allow save up the 100 for the 23andme test. A practitioner will cost you easily 500-1000 bucks for testing and feedback/supps.
With the MTHFR mutation you can treat it through diet by eliminating folic acid fortified foods (cereals, breads, anything with flour in it, and grain products) for starters.
B vitamins and B12 are kinda essential - i buy the 'B-Right' from Jarrows - it has many of the bioavailable forms of the B's in it, instead of all synthetic B's which most supps have.
Again - see how you go with B vits - they can give symptoms.
Again restricting folate foods i have found to benefit me, even if it is 'natural folate' from greens for example. There's a bit of controversy whether natural food folate is good for MTHFR people or not, but essentially the body still has to convert folate to methylfolate using MTHFR so if that gene is not working well, that conversion won't be done...giving you a high blood folate but a cellular deficiency.
Methyl Folate supplements are what is needed really. Alongside a good B12 (methylcobalamin, adenosylcobalamin and hydroxycobalamin - depending on gene results). Vit C too. That's a stripped-down protocol.
Certainly just stay away from all food with folate and folic acid.
Niacin also absorbs methyl donors, so it's not that great for someone with MTHFR. It's good to take if once you start on methylfolate supplementation, which introduces methyl donors to the body, causing detox to start, if the detox reaction is too much, taking niacin helps to calm down symptoms due to it's actions of absorbing methyl.
Over-methylating people do well on niacin. MTHFR people have very little methylation occuring and generally are under-methylated.
It's best to follow a MTHFR protocol once you know you have it. In the meantime try the fail-safe diet elimination route and GABA for the bouts of anxiety. That's the cheapest method i can think of in your situation.
It takes some planning and diligence even to focus just on diet and sticking to it, when plagued with symptoms, so keep it simple and start from there. Be strict with yourself. As an aside note i read often many naturopaths and MD's say we are generally addicted to the foods/drinks we are allergic to, so keep that in mind when analysing what you eat...it's worth trying to go without the food you most desire to see if symptoms change.
Keep us posted on how you get on...CZ is a great place for support....good luck :-)- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,396
This is a reply to # 2,088,172That's very interesting to me. On the one hand, I can see how I would be addicted to the foods that are harming me-- I'm no stranger to addiction. At the same time, I've heard a lot about how the body will often crave the things it needs. I tend to crave blueberries, avocados, dates, mushrooms, garlic, and eggs. Maybe this is something I should take into consideration while cutting out foods and observing the effects.
I also know that my vegetarianism might not be helping symptoms much, but from a personal ethical point of view I find it very difficult to even consider eating meat.
Is GABA potentially dangerous to take?
Also, will folate fortified foods be labeled as such? Will it appear as an ingredient or a note on the box (many almond milk brands I purchase are marked as Vitamin D fortified, for example).- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,690
This is a reply to # 2,088,210I agree also that we crave what we tend to nutritionally need also! It's hard to distinguish cravings. These days i keep an open mind about why i'm craving something.
Funnily enough the foods i most crave are avocados, eggs and mushrooms! I feel terrible without eggs in my diet. Garlic i added to everything i made...i love the stuff...but i've found less digestive troubles by completely eliminating it from my diet.
I rejected meat as a child...i would feed it to the dogs under the table at meal times. When i was 16 and moved out of home i naturally became vegetarian. It was not an ethical choice for me but one of taste preferability coupled with much better digestive health. As a child i was severely constipated which came to an end when i stopped consuming flesh.
It's not a diet i recommend for everyone...and certainly am not a pusher of a meat-free way of life.
It would be much much muuuuch easier for me calorifically and nutritionally if i could eat meat...but i'd rather have bowel movements and better bowel health!
The last piece of flesh i consumed was salmon caught fresh by my father from the sparkling clearest waters of Scotland - and i had the worst bowel issues i ever had in my life and literally no bowel movement for 10 days afterwards. I was so ill.
Genetically my reaction to meat can be explained due to it being a high ammonia producing food, as well as high histamine (fish especially) and those genes are severely mutated leading to already high ammonia and histamine in my system. Meat pushes me over the limit with these chemicals and causes severe symptoms.
Go with what your body can handle...
There are many many protein options for non-meat eaters. I really recommend quinoa as it contains the 9 essential amino acids. Braggs liquid amino's contains a huge amount of amino acids. There are amino acids in many foods. Eggs are a great source of protein and choline...and Ray Peat says that potatoes are an excellent source of protein.
Living in Ireland i know potatoes were the staple of the diet for many generations and only due to the blight affecting potato crops did hundreds of thousands die. Meat was too expensive and so potatoes were relied upon. So my opinion of the potato has switched to it being an excellent staple.
It has also been a staple of the Aztec's who still to this day grow various varieties and rely on it.
GABA in my opinion is a safe supplement. Obviously with any supplement it is best to have a low dose and gauge how you feel.
It's not like taking tryptophan or L-dopa which, if you already have high levels, taking more will cause worse symptoms of serotonin syndrome...high dopamine.
I tried SAMe as it's good for liver health and relieves depression. Everyone says it's fabulous. I tried one pill and became extremely agitated, anxious, depressed, suicidal...it was awful. I locked myself in a room for 2 days knowing it was the SAMe and would end. I didn't know it then but SAMe is a huge methyl donor - i took 450mg....being MTHFR it basically caused a huge detox to occur. Everything swirling around my system not being expelled. When you consider that taking just 1MG of methylfolate causes a severe herx reaction for a MTHFR person, taking 450 times that amount is lethal.
I didn't know i was MTHFR at the time.
The dosage of GABA is recommended at 2 x 500mg a day. I take phenibut which is an altered form of GABA to pass by the blood brain barrier, giving an effect within 1 hour of taking it... all i take is 250mg per day. 500mg all at once makes me sleepy.
Caution of Phenibut - party-clubbers abuse phenibut to give them a confidence boost and to make them ultra-sociable when clubbing. They take in the region of 1g-3g at a time. That's a huge dose. It works great for many and they become addicted. But the downside is that when they stop it they have worse jitters and anxiety than they ever experienced, because they're suddenly depriving themselves of a major 'calming' chemical.
The web is loaded with info of people taking it in this fashion and warning others not to take it.
I take it therapeutically, and am sensitive to chemicals, and would never take over 250mg at a time, despite being an 'addictive' type of person. I have never had a problem using it wisely, i generally take it for 3 days...stop for 3 days, take some more.
With GABA - it takes a while to build up in the system, a couple of weeks, as it doesn't readily cross the BBB so easily as phenibut, so i would start with 250mg, see how you feel, if no adverse reactions...try 500mg a day...see how you feel...and continue like that. It depends if you're naturally sensitive to supplements and drugs. I am. So i always react.
Like with any neurotransmitter enhancing supplement - if you want to stop it it is best to wean off slowly. Otherwise you'll crash the other side if you stop suddenly.
I've never experienced this as i take low dosages.
Generally GABA is cheaper than phenibut. Like i said before i'm going to switch to GABA when i finish this phenibut as it works well for calming me and i'd prefer to have a supply of it feeding slowly through my BBB than dosing 'as and when' with phenibut.
Folic acid fortification is normally labelled. You'll have to check. I don't buy from supermarkets so i'm not sure on general labelling of goods these days but i'm sure it's law that it has to be labelled.
Don't try to do everything at once with diet and supps - that itself can create more anxiety! Start with diet elimination. If anxiety is a huge problem right now making it impossible to function, consider GABA too.
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,483
This is a reply to # 2,088,225Sorry, one more question. I just realized two of the supplements I recently started contain L-5-methyltetrahydrofolate. Together, they provide 900 mcg. Is that a good amount?
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,511
This is a reply to # 2,088,249Yes, that's adequate if you're MTHFR. Many people start with a quarter of that dose.
What are your reactions to the methylfolate if any?- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,426
This is a reply to # 2,088,264It's difficult to say what was caused specifically by that.
After starting on Somnolin (Metagenics), which contained the Folate along with 5-HTP and some other things, I began to feel better slowly, with waves of relief followed by waves of Depression and anxiety.
A bit less than a week ago, I began taking Ceralin Forte, also from Metagenics. http://www.metagenics.com/mp/products/ceralin-forte
The first thing I noticed, even only the day after, was a mental awareness that I hadn't had before. However, a few days later, that began to go away, and I began to experience so-called 'brain fog' as well as panic attacks. At this point, I feel as though I'm cycling between the two quite a bit. Every so often, I feel ok. Every so often, I feel very anxious.
One thing I can say with certainty is that, a few days after taking Ceralin Forte, my Acne began to clear. This is surprising, because the supplement is intended to help the nervous system mostly, so I'm guessing it's mostly the methylfolate that would be helping with acne, and not any of the other ingredients. After the initial feelings of awareness and energy, I began feeling much more fatigued, which I still feel much of the time. But like I said, it hasn't even been a week.
I also realized that the orange juice I drink (I drink a lot of it, another craving of mine-- maybe for the vitamin C) is fortified with quite a bit of Folic Acid. I found some Vitamin C supplements in a cabinet in my house, which I may begin taking in place of the orange juice.- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,667
This is a reply to # 2,088,279I too have felt the waves of feeling better and then feeling worse, mainly in 2 week segments of each.
The ingredients of the Somnolin with 200mg of 5-HT is a good high dose. However, for you it may be helping bringing you relief from perhaps low serotonin, but if high serotonin is a problem for you it can cause worse symptoms after a while. With 5-HT i feel very agitated and moody! The methylfolate (IF) you are MTHFR +/+ will cause detox symptoms, which could be the waves of Depression and anxiety.
I definately get more anxiety when detoxing with methylfolate.. An inner jittery feeling, sometimes my hands are physically shaking. I don't want to see anyone and can't focus on anything. Energy levels are very low too.
You have 65mg of B6 in total with both supplements in there which is the HCL version of it requiring conversion by your body to form the bioavailable p-5-p version...again IF you have a CBS gene upregulation, it is said that B6 is not recommended for this. I'm personally unsure of this but it perhaps causes more ammonia production, which pushes on the adrenal for cortisol production, high cortisol = anxiety (in some people if chronic).
B6 can cause better dream recall - have you noticed this on these supplements?
The Acne could be helped by NAC , i found it similarly helped my skin condition, perhaps due to better glutathione levels...however again with CBS gene NAC is a high sulfur supplement which aggravates ammonia production.
They look like good supplements for people without the methylation issues but if you do have these issues you could easily be going through phases of detox and clearing, bringing waves of symptoms as you experience.
The Ceralin contains niacinamide which would absorb methyl donors so it opposes the job of the methylfolate in that supplement. As Dr Ben Lynch says "It's like putting one foot on the brake and the other on the gas".
The carnitine is a good element of Ceralin, energy-giving.
Have you tried one day on, one day off with the supplements?
Are you taking them daily?
However, if you are an over-methylator adding all the extra methyfolate could equally cause symptoms.
This is why sometimes individual supplements are best as it's easier to gauge how you respond.
You could try 100mg of niacin, or 250mg non-flush niacinamide. It's a very cheap supplement. See how you feel on that - it over-methylated this should improve symptoms. If under-methylated symptoms worsen.
For me, niacin makes me easily flush, i feel quite nauseous and jittery anxious 1/2 hour after taking it and for a few hours more...but the next day i can have an increase in energy.
Taking niacin that causes a flush also helps you determine if you have high histamine levels. If you flush heavily from 100mg Niacin it *could* indicate high histamine levels.
As you already have these supplements, i would stagger dosage to 1 day on and 2 off...that way you get the few hours after dosage to monitor symptoms, the next day once fully assimilated to monitor symptoms, and the day after that to see how you feel off them. If symptoms don't change that drastically for you, perhaps try 5 days on and 5 off.
I've taken supps. daily to stick to a strict regimen before, and any bad symptoms i put down to 'detox' but in reality it's always been the wrong supplement in the mix of stuff i've taken.
When able get the supplements seperately, try them slowly each one, low dose...monitor how you feel. Then when you know B12, folate and B6 work for you you can buy a multi-vit in the future.
Multi-vits in my opinion are not a good idea to these intolerances many people have to one or two ingredients.
I too get orange juice cravings - like you i think that's due to the need of Vit C. Taking Vit C supplementally in 1G dosages is a way to make sure you're getting enough. As you mentioned nicotine use it is best to try to get 2G per day of Vit C as it robs Vit C.
It takes time to build-up the body reserves of good nutrients after a time of neglect and abusing the body as you mentioned in your opening post, so rely on getting plently of good food into you, really curbing the stimulants and know that you're on the road to recovery.
Most on this forum are where you are at or have been so keep asking questions and don't give up!
- 200mg 5-HTP dose experiment purplepixie
11 y
8,873
This is a reply to # 2,088,313Hi,
I took 200mg of 5-HTP Griffonia Seed extract this morning, as is the dose on the supps you are taking.
My general physiology is of low serotonin, and i have only ever taken 50mg before.
Within 10 minutes after ingestion i became very nauseous and hot, i had to lay down as the nausea was raging and my system desperately wanted to vomit. Increased sweating and heart rate. Digestion rumbling. My throat closed up.
Symptoms remained for 1.5 hours as i laid down. I managed through breathing exercises not to vomit.
Then i became very tired.
3 hours later i am up and about, feeling sensitive, agitated, slightly anxious and easily panic-ed, sensitive to sound and light.
I never had this experience with 50mg.
My experience seems similar to serotonin syndrome toxicity effects, if only mild.
So perhaps having 200mg as one dose could be causing your symptoms?
- 200mg 5-HTP dose experiment purplepixie
11 y
8,873
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,667
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,426
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,511
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,483
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,690
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
8,396
- Re: Anxiety, depression, and more. I... Blistering Fate
11 y
8,550
This is a reply to # 2,088,033Hey, I have some degree of Asperger´s and some symptoms in common with you (mainly the mental/social ones). What purplepixie says its very valuable, I am a male of 22 years old as well and have had time and tools already to try also some stuff, reiki, meditation, supplements, candida diet and what not. It seems nutrigenomics truly has something to offer to the chronically ill. Trust me 100 dollars its nothing I have wasted thousands of my parents money in tests only to discover I am awfully defficient in most hormones and nutrients/antioxidants... Got 23andme and it has answered some questions, but it sucked to see that my detox genes (not the methtylaton ones) are f***ed, because these are not the ones yasko targets. Although I also have methylation mutations of course. Have to try methylation myself yet but I know physical detox and clearing emotional traumas its the way to go. Toxins IMO are the cause of lots of problems like AF, either emotional or physical (heavy metals etc.
There are other crucial things to consider like Leaky Gut Syndrome, but if you have this and also glutathione depletion you will need a methylation protocol anyway to heal it.
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,859
- Re: Anxiety, depression, and more. I... Blistering Fate
11 y
8,545
This is a reply to # 2,087,955Very good info in CBS and AF. If thats the case, its clear why I have adrenal fatigue, with my double CBS c667t and double BHMT 8. Also, it explains why I always was sympathetic dominant to begin with.
How do you know you have 5 mutations in GAD? Do you surf raw data in 23andme? I saw that I have more mutations that the ones on genetic genie, but they are not "scientifically validated" or something so I dunno what it means. I mean, if I type "MTHFR" in the raw data I get that I have at least 50% of mutated genes, some double some heterozigous, from all the MTHFR alleles, but on genetic genie I just have two heterozygous MTHFR mutations.
It seems I have 3 double GAD1 mutations, 3 normal and 9 heterozigous... So my genes are autistic! Yep. Do the normal genes counteract the mutated ones in their effects? Silly question, probably. Do you know more significative genes to research?
I see you have posts from 8 years ago with the old good Colon Cleanses and stuff, proving what you told the guy earlier. I have gone trough that as well...- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,384
This is a reply to # 2,089,054Heya BF :-)
I got the info on my other gene results from:
https://livewello.com/23andme
For 20 bucks you upload your 23andme results into their app and they give results for over 290 genes to do with methylation, detox, immune function etc.
It's the best 20 bucks i spent on top of the 100 for 23andme! Saved me weeks of going through the genes myself.
GAD gene is a b*tch...it should convert glutamate to GABA...so far research shows this is impaired if mutated...sounds like yours is as bad as my function in this area. The upside is lots of glutamate for brain function...but that function is hyper and hard to control ;-), downside being less GABA in the body and brain for calming often leading to ADHD, autistic behaviours, and anxiety in adults.
I've suggested to the mods to start a nutrigenomics support forum for folk interested in this and for those doing it to share info and experiences...would be great to have some support in this request...helps to keep this kind of into in one place instead of scattered around the whole of CZ:
//www.curezone.org/forums/fm.asp?i=2087982#i
Today i've been researching the MAOA and B genes and their correlation with depression. It's astounding how these genes really do seem to pre-dispose us to these conditions.
I often surf the raw data in 23andme. If we have mutations in a gene aswell as normal gene expression, it all depends on research done on those particular snp's to know whether the normal genes cancel out the function of the mutated genes. Oftentimes the snp's are shown in studies to alter function despite the 'normal' snp's in the same gene. Also it depends on that enzymatic function and whether another gene also 'makes up' for that mutation - which can sometimes be the case.
The genes i think most important to dig into are the ones mentioned by Yasko, geneticgenie, but also the ones given on the livewello app. The result livewello give also contain links to studies done on that particular snp....which helps us understand better the function of that gene and effect of it being mutated.
Hope all this makes sense...i've had a weird day from the effects of the high 5-HTP dose!
- Re: Anxiety, depression, and more. I... Blistering Fate
11 y
8,474
This is a reply to # 2,089,157Yeah I have the homozigous MAO A , thats what makes me so emotionally reactive and mentally troubled, among other factors.
Cool, I know where to upload my genes then, thanks a lot!
For the record, 5HTP made me get scary depersonalization, could be because of my serotonin metabolism.
- Re: Anxiety, depression, and more. I... Blistering Fate
11 y
8,474
- Re: Anxiety, depression, and more. I... purplepixie
11 y
8,384
- Re: Anxiety, depression, and more. I... Iwanttofeelok
11 y
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- Re: Anxiety, depression, and more. I... shotsee
11 y
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This is a reply to # 2,087,736Hi IWTFO,
As "grist for your mill," are you aware of the almost miraculous results many tens (hundreds?) of THOUSANDS of people have experienced, dealing with MOST of the health issues known to humankind, from ingesting the powerful antioxidant, ascorbic acid?
If you are seriously interested in finding a solution to your health problem(s), and gaining better health in ALL areas of your body, I STRONGLY encourage you to read [at least the first ten paragraphs of] this article written by Dr. Robert Cathcart, M.D. http://vitamincfoundation.org/www.orthomed.com/titrate.htm
It may just solve some or all of your problem(s). You have only better health and well-being to gain by applying its recommendation. What have you got to lose?
These two quotes are instructive:
"There are more than ten thousand scientific papers that make it quite clear that there is not one body process (such as what goes on inside cells or tissues) and not one disease or syndrome (from the common cold to leprosy) that is not influenced - directly or indirectly - by vitamin C." -- Dr. Emanuel Cheraskin, M.D., Dr. Marshall Ringsdorf, D.M.D., and Dr. Emily Sisley, THE VITAMIN C CONNECTION.
“I have never seen a patient that Vitamin C would not benefit.” -- Dr. Frederick Klenner, M.D.
I wish you BEST success, IWTFO, in your search for a solution to your health issue(s)!
Sincerely,
David
- Re: Anxiety, depression, and more. I... koifishgal
11 y
8,614
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