"not heard of one single instance of an over-iodiner" DYING of it

wombat: " but I have not heard of one single instance of an "over-iodiner" DYING of it. "

Aye: Are you even at a point after such 'blatant' display of emotional attachment where you would have ears to hear it?

"Concerning the report of deaths due to high-dose iodine, here is the pertinent reference:
Sterling JB, Heymann WR. Potassium Iodide in dermatology: a 19th century drug for the 21st century – uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol. 2000;43:691-697.

In this review article, the authors state that in the 1920s and 1930s, when potassium Iodide (KI) was widely used, many patients died of KI-induced side effects, particularly pulmonary edema and associated heart failure

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Abstract
Death by oral ingestion of iodine
Nicholas A Edwards11Intensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, South AustraliaDr Nicholas A Edwards, Intensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia. Email: nedwards@mail.rah.sa.gov.auNicholas A Edwards, MBBS, FRACP, FJFICM, Staff Specialist; Paul Quigley, MBChB (Otago), Senior Registrar Emergency Medicine; L Peter Hackett, Research Scientist; Ross James, MBBS, FRCPA, Specialist Forensic Pathologist (retired)., Paul Quigley22Sir Charles Gairdner HospitalNicholas A Edwards, MBBS, FRACP, FJFICM, Staff Specialist; Paul Quigley, MBChB (Otago), Senior Registrar Emergency Medicine; L Peter Hackett, Research Scientist; Ross James, MBBS, FRCPA, Specialist Forensic Pathologist (retired)., L Peter Hackett33Clinical Pharmacology and Toxicology, The Western Australian Centre for Pathology and Medical Research, Perth, Western AustraliaNicholas A Edwards, MBBS, FRACP, FJFICM, Staff Specialist; Paul Quigley, MBChB (Otago), Senior Registrar Emergency Medicine; L Peter Hackett, Research Scientist; Ross James, MBBS, FRCPA, Specialist Forensic Pathologist (retired). and Ross James44Forensic Pathology Department, Forensic Science Centre, Adelaide, South Australia, AustraliaNicholas A Edwards, MBBS, FRACP, FJFICM, Staff Specialist; Paul Quigley, MBChB (Otago), Senior Registrar Emergency Medicine; L Peter Hackett, Research Scientist; Ross James, MBBS, FRCPA, Specialist Forensic Pathologist (retired).1Intensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, 2Sir Charles Gairdner Hospital, 3Clinical Pharmacology and Toxicology, The Western Australian Centre for Pathology and Medical Research, Perth, Western Australia, and 4Forensic Pathology Department, Forensic Science Centre, Adelaide, South Australia, Australia
Dr Nicholas A Edwards, Intensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia. Email: nedwards@mail.rah.sa.gov.au
Nicholas A Edwards, MBBS, FRACP, FJFICM, Staff Specialist; Paul Quigley, MBChB (Otago), Senior Registrar Emergency Medicine; L Peter Hackett, Research Scientist; Ross James, MBBS, FRCPA, Specialist Forensic Pathologist (retired).

Abstract

We report the clinical and toxicological features of a case of fatal Iodine ingestion, and summarize the physiology, clinical characteristics and management of Iodine ingestion. Physicians are likely to have little experience in managing such patients, particularly with the advent of less toxic preparations, and therefore need ready access to management guidelines. This case also highlights the potential for substances to retain their toxicity over long periods of time
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The toxicity of Iodide excess has been demonstrated, both in animals and in cell systems. Involution of the thyroid gland has been described in rats fed with an iodide-rich diet (3, 4). In vitro, iodide inhibits thyroid cell growth and induces morphological changes in porcine thyroid cells (5). Some effects of iodide seem to be species specific. A cytotoxic effect of iodide has been documented in rat FRTL-5 cells but not in primary dog thyrocytes (6). The iodide-induced cytotoxic effect on rat thyrocytes included necrotic and apoptotic features, indicating the involvement of a controlled process of cell death. Apoptosis (or programmed cell death) is an active process of cell self destruction requiring the activation of a genetic program, leading to changes in morphology, DNA fragmentation, and protein cross-linking (7, 8).


http://endo.endojournals.org/cgi/content/full/141/2/598

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