excellent article. only concern I see is differentiation and variation, variabilities. say humans are as complex and variable as the fish in the ocean. some fish are mud guppies, bottem feeders, carp etc, some fish must live in tropical, saline water, some fish are hammerheads that can live in fresh water only, other fish thrive in salt water only. we are as diverse as the fish of the ocean I believe in variation, so each fish has a prefered homeostasis and optimal environ extenally and intracellularily, same with each human, adaptation and variation within the human family as in the fish family is considered.