It's all natural - magnolia officialinalis and philodendrun. I've recommended it on another forum, where a lot of people are depressed, and many of them like it, too. I recommended it to you, because it sounds like you are tired of all the pharmaceuticals? As you may have seen by the post below, I also found some lithium (a mild form). I can't take it, because it brings me into severe depression, and I had a reaction to it, but it helps my husband. He likes his highs because he gets a lot done, and his personality becomes hilarious, plus he has a lot of talent. But he gets pretty wild and angry after awhile, so I have to remind him to take them.