the last time i talked to julia, i forget what i asked her, but she said the only one she still takes is the bitters. she said that she detoxified her liver quite awhile ago, and since then she doesn't need the coptis, gcg, and curcuma. but she is the most disciplined person i ever met. she exercises every morning, she never eats sugar, the only tasty drink she has is a glass of apple juice every morning. i could go on, but the point is, she doesn't need to keep taking them because she doesn't congest her liver. so once you get your liver cleaned out, you may be able to stop some of the stuff, and then when your body is telling you something is wrong, go back to the ones that you need. but i guess the bitters could be a forever thing, if you like what it does for you.