I do
It works better for me than any other liver herb. I've used milk thistle, artichoke extract, Swedish Bitters, etc.....all made me WORSE.
Bitters doesn't seem to stimulate my appetite, but it keeps my complexion clear and just all around works better for me than anything else I've tried for the liver.
I'm not sure what you are looking for in terms of symptom relief so I cannot comment on why you don't "notice a difference".
If I didn't break out, I don't know that I would "notice a difference" either, but I do know that my breakouts cease when I use the CB, and when I use Curcuma at night, I sleep like a baby. I used to have to take 5-6 mgs. of melatonin in order to sleep, and sometimes that didn't even work. Herbs like valerian, hops, passion flower, etc....didn't even begin to touch my insomnia.
Overall, I would say these herbs from sensiblehealth work better than anything else I've tried, and I've tried EVERYTHING as I've been into natural healing for about 13 years. Ofcourse everyone is different.