the fact that taking enzymes lessens the reported effect is very telling and inline with leaky gut which in turn is inline with dysbiosis. There may also be a "total load issue and where the food/digestion may be tipping the apple cart so to speak but not the main culprit. Look to external environment for clues such as dust, mold, chemicals, emf , etc.
I would work on the intestines, liver and kidneys first. Stay alakline. Also watch your food combinations. Dysbiossis and autintoxication can take time to sort out.