Re: might be true for some, but not others. do your homework people, get tested first...
Hello John,
After spending some time looking at this, I have come up with the following...
1.25 D levels vary according to the bodies ability to absorb nutrients from the diet. High levels are directly caused by low serum levels of calcium and phosphorus and are greatly influenced by parathyroid hormone imbalances. A lot of the studies supporting this were done both in humans and in animals and date back to the 1970's. Studies done later than 2000 have added magnesium to the list.
While there isn't a lot of correlation data between 25 D levels and 1.25 D levels I think we can look at what causes an increase in the 1.25 D levels and go from there.
This indicates that if your body has thyroid "issues" and can not absorb calcium, phosphorus, and magnesium from your diet, you will end up with elevated 1.25 D levels.
Jumping to the co-factors involved with vitamin D we find that they are magnesium, zinc, vitamin K2, boron, genestein, and some vitamin A.
Since 1.25 D levels have been shown to be inversely proportional to serum calcium levels, you can lower your 1.25 D levels by increasing the serum calcium levels. However, in order to absorb calcium into your body, you need vitamin D. Also, in order to have an adequate amount of vitamin D, you need magnesium, zinc, and the other co-factors associated with vitamin D.
When we start looking at electrolyte imbalances, thyroid imbalances, and zinc and calcium deficiencies, we may be able to address most illnesses. Now compound this by suddenly deciding to increase your vitamin D levels and you can mess up a whole lot of body functions.
Here is an example of this. I know of a person that found that their 25 D levels were low, and they decided to increase these levels. They felt that they were in pretty good shape overall, so no further testing, or consideration was done. Over a period of time, the 25 D levels steadily increased until they got to the therapeutic levels. Suddenly, this person developed heart palpitations.
Now we took a closer look at what was going on. We discovered that electrolyte balance was very important to body functions, including heart rhythm, and to the absorption and utilization of vitamin D. A close detailed look at diet revealed a magnesium deficiency. Blood tests showed magnesium in the low normal range, but it seems that this person needed to be in the normal to high range for their body.
Further research revealed the following:
Calcium, magnesium, sodium, and phosphorus levels need to be in balance and adequate for optimum health.
These electrolytes require vitamin D to allow absorption from diet and supplements.
However, vitamin D requires the electrolytes in order to function.
An electrolyte imbalance can effect heart rhythms.
Diet can be deficient in trace minerals and can alter electrolyte balance.
After a round of magnesium supplements and a diet change, the heart palpitations went away and things are back to normal.
Now, let's put this all together...
Elevated 1.25 D levels have been shown to be reduced by increasing serum calcium. In order to increase serum calcium through diet, you need adequate levels of vitamin D and have an adequate intake of calcium. In order for vitamin D to work, you need to have adequate supplies of the co-factors including magnesium and zinc.
The bottom line appears to be that if you have elevated 1.25 D levels, you need to elevate your 25 D levels, make sure you have the vitamin D co-factors addressed as well as any electrolyte or thyroid imbalance, and then you need to increase your calcium intake. According to the testing that has been done in animals and humans, this will bring your 1.25 D levels back into its normal fluctuating range.
Tom