Re: can too much alkaline be too acidic???

The reason of low pH is cellular hypoxia. Consider these quotes:

Abstract ….In addition to oncogene activation and transformation, hypoxia is responsible for inducing acidosis through a shift in cellular metabolism that generates a high acid load in the tumor microenvironment.
J Cell Mol Med. 2009 Dec 8. [Epub ahead of print]
Tumor hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.
Chiche J, Brahimi-Horn MC, Pouysségur J.

Abstract…. Considering that activation of HIF-1 provokes pro-survival as well as pro-death decisions under hypoxia, it will be crucial to understand decision making processes in regulating cell death, adaptation and chemoresistance. Likely, secondary stressors such as pH changes, i.e. acidosis, and the context of genetic alterations will shape the role of HIF-1 to affect susceptibility of cells to undergo hypoxia-induced cell death or to allow adaptation and progression towards malignancy.
Cancer Lett. 2006 Jun 8;237(1):10-21. Epub 2005 Jul 5.
Tumor hypoxia and cancer progression.
Zhou J, Schmid T, Schnitzer S, Brüne B.

Abstract …. Hypoxia activates a complex gene expression program, mediated by hypoxia inducible factor 1 (HIF1alpha). One of the consequences of HIF1alpha activation is up-regulation of glycolysis and hence the production of lactic acid… These mechanisms contribute towards an acidic extracellular milieu favoring tumor growth, invasion and development.
Cancer Metastasis Rev. 2007 Jun;26(2):299-310.
Regulation of tumor pH and the role of carbonic anhydrase 9.
Swietach P, Vaughan-Jones RD, Harris AL.

Abstract. The hypoxia-inducible factor is the key protein responsible for the cellular adaptation to low oxygen tension. … Not only does the microenvironment impact on the hypoxia-inducible factor but this factor impacts on microenvironmental features, such as pH, nutrient availability, metabolism and the extracellular matrix.
Cancer Microenviron. 2008 Dec;1(1):53-68. Epub 2008 Mar 19.
A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment.
Dayan F, Mazure NM, Brahimi-Horn MC, Pouysségur J.

Abstract. At a molecular level, hypoxia induces the stabilization and activation of the alpha-subunit of an alpha/beta heterodimeric transcription factor, appropriately termed HIF (hypoxia-inducible factor)… Therefore HIF plays a key role in tumorigenesis, tumour development and metastasis, and its expression in solid tumours is associated with a poor patient outcome... Whereas normal cells metabolize glucose through a cytoplasmic- and mitochondrial-dependent pathway, cancer cells preferentially use a cytoplasmic, glycolytic pathway that leads to an increased acid load due, in part, to the high level of production of lactic acid.
Essays Biochem. 2007;43:165-78.
Hypoxia in cancer cell metabolism and pH regulation.
Brahimi-Horn MC, Pouysségur J.

Why do you have low body oxygenation? For example, if you breathe too much (or deeply).

When a person breathes more than the medical norm at rest, over-breathing (or hyperventilation) REDUCES body oxygenation. This physiological law is based on 3 fundamental observations or facts of respiratory physiology:

1. Red blood cells are about 98% saturated with oxygen during miniscule normal breathing (6 l/min; 12 breaths per min; 500 ml for one breath; diaphragmatic, strictly nasal, invisible, inaudible). Hence, when we breathe more than the medical norm, we cannot improve, to any significant degree, arterial blood oxygenation.

2. Hyperventilation (overbreathing) decreases CO2 concentration in the arterial blood and other cells causing constriction of arteries and arterioles since CO2 is a vasodilator. As a result, breathing too much leads to reduced blood and oxygen supply for the heart, brain, kidneys, liver, colon, and other vital organs. (This is reason why we can easily faint or pass out, if we try to breathe very heavy for 2-3 min: oxygen availability for brain cells is reduced about 2 times.)

3. Less CO2 in the tissues means a shift in oxygen dissociation curves for blood to the left causing “suppressed Bohr effect” (a reduced oxygen release by the red blood cells in the capillaries).

Therefore, the more one breathes, the less oxygen is provided for vital organs.

Hence, you should learn how to breathe less for better body oxygenation.


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