Thanks for that explaination! It's an interesting theory, but here's the part that makes me question: is bowel tolerance really determined by how much Vit C you can use or how constipated you are? I'm sure I've already taken 9 grams Vit C today along with 6 Oxypowder last night and 4 this morning - and only had one *solid* visit to the restroom. Yes, I do have chronic constipation (partly the reason for Iodine + Oxypowder + Liver Flushes). I'd imagine both constipation and need for Vit C are variables that affect this. It's possible I can make use of much Vit C because I took a bunch of Iodine yesterday (I think over 100mg). hmmmmm