Thank you for your response. I have been taking A*****ose for 8 months and have been detoxing in cycles since then but when I increased my Plus from 3 a day to 4 a day the detox got worse about 1 week after the increase - much worse for about 3 weeks - I suffer from vulva pain - it stems from a pudendal nerve problem which compresses my nerve and is causing nerve damaged so it causes pain in my vulva. I have been getting pain or 13 years but the pain has worsened the past 4 years. Since starting the A*****ose the pain got even worse until the past 3 months - now I get bad pain for about 3 days then no pain but headaches for awhile and then 3 days with pain again - each time the time with no pain in between gets longer - first it was 6 days, then 11, then, 14 and this last time 23 days. Now today I have pain- oh and I get really, really tired and I am achy. I think detox. I really don't want to reduce the Plus or anything I just want to stick it out - I figure if I reduce than it will be longer for better health - why not just stick it out and get better faster - I'm already used to feeling crappy anyway. I just want to feel good and be healthy. If I have to feel bad to get there that's okay as long as I know I'll get there. Thanks for listening.