It's probably hormonal
I know that I am doing my body good by taking this so I just take a lot.
I assume that you are talking about A*****ose. Because you got the detox symptoms with the increase in PLUS, why don't you go back to the original dose for a week or so and give yourself a break?... Or halve the difference in amounts and see if that makes a difference? Apparently you were already getting many benefits before you increased the amount. Have you perceived any new benefits at the increased amounts of PLUS, or are you just suffering from the detox symptoms?
The water intake sounds great. Are you using filtered water, at least? It is important to help the liver and kidneys with removing and flushing the toxins. Fruits and veggies, good.
PLUS is designed to provide precursor molecules for the body to make hormones according to its priorities. There are 87 identified hormones, and malfunction with just one of them, insulin, can cause death. People differ greatly with their response to hormone production. I find women to be incredibly complex animals with the ebb and flow of hormones and extreme individual variations of their responses. It applies to men also. There are men who suffer from satyriasis who show low levels of blood testosterone while others, who have much higher than average, are apparently normal. Women on birth control pills who suffer from cramps and clots often stabilize with pills that are 1/50th the strength of a regular prescription. When you tinker with hormones, results are predictible, but still have many exceptions and variations, so you need to observe and adjust. Just imagine what a doctor using horse hormones on human women has to deal with! Add to hormonal amounts the variations in nutritional status with multiple deficiencies and it becomes incredibly complex.
"Detoxing in cycles?" Yes, quite often and especially in women, but I find that women are more likely to be working on themselves and paying closer attention, than men.
My wife initially found that taking PLUS made her feel "wired," so tense that her nerves felt like "guitar strings." After a few months on A*****ose, she found while trying PLUS again that that had passed but she still did not like it because she got angry so easily and had no patience with slow, stupid, or obnoxious people. My nephew found that his sex drive increased tremendously, in his early 40s. A 70 year old colleague found that her period seemed to be trying to revive. An acquaintance reported that he was losing fat and gaining strength and energy. I could go on at length, but I seem to get no effects, even taking 8 a day, except maybe increased irritability.
So my advice is: You take charge of your health. Your doctors, M****tech associate, and others may have helpful advice, or not,... but you are responsible for your life.
musashi