Hi all. I have been on progesterone cream and Triest (a estrogen capsule)for well over a year. They both are done at the compound pharmacy. Interesting though, I gained 10 lbs. this year and the dr. seems to think that the hormones are bogging down in my liver. I saw an earlier post that stated someone was using a progesterone suppository to bypass liver. That sounds like a possible solution. Will have to check into it.