My step-father started taking LDN Jan 1st 2003, at that time, he was and is restricted to a wheel chair, due to spasticity in his right leg, however since taking it, he indicates that he hasn't lost further functionality, and due to the relief of symptons, he has actually regained some slight mobility in the right leg, this isn't to say it's a reversal, it just means without the apparent afffects of MS actively affecting his system, he seems to have built back up some strength in that leg, we realize he may never be able to go back from the wheel chair, but it's nice to think he may not get any worse. If you wish for more anecdotes and other info, goto www.ldninfo.org that's where we discovered it.