Re: fenbendazole is working

interesting finds:

Pharmacology:
Fenbendazole is a benzimidazole anthelmintic, that has broad spectrum, and a wide safety margin.
It binds to 3-tubulin astructural protein that blocks polymerization of tubulin into microtubules, which damages the integrity and the transport function of cells in parasites. The reason behind the wide safety margin is due to its infinity to the parasitic tubules rather than mamilian.
The drug is minimally absorbed after it is given orally. It is metabolized to the active compound oxfendazole sulfoxide and sulfone.
Fenbendazole is excreted in the feces and urine.




(for veterinary information only)

BRAND NAME: PANACUR

AVAILABLE IN
ORAL SUSPENSION
AND GRANULES

BACKGROUND

The care of animals has always included the management of internal parasites. As technology has progressed, the medications developed have become more and more broad in the spectrum of parasites they can eradicate. Fenbendazole is a member of the benzimidizole group of anti- parasite medications which makes it a relatively broad spectrum product.

HOW THIS MEDICATION IS USED

Fenbendazole (often abbreviated “FBZ”) is used in both large and small animals. In dogs, it is useful against roundworms, hookworms, and the more difficult to treat whipworms. It is effective against the Taenia species of Tapeworm but not against the Common Tapeworm Dipylidium caninum. It is also effective against giardia, a protozoan and several species of lungworm and even some flukes.

Fenbendazole is rarely required for feline use but can certainly be used safely in the cat. Fenbendazole is not approved by the FDA for use in the cat, however.

SIDE EFFECTS

Some animals experience vomiting/nausea after deworming.

INTERACTIONS WITH OTHER DRUGS

There are no significant drug interactions in small animal use.

CONCERNS AND CAUTIONS

Fenbendazole is considered safe for use in pregnancy in all species.

Treatment is necessary for three consecutive days. Treatment may require a second course depending on which parasite is being treated.



http://www.inchem.org/documents/jecfa/jecmono/v29je04.htm


http://72.14.203.104/search?q=cache:P3sLHvlLwXUJ:www.emea.eu.int/pdfs/vet/mrls/086603en.pdf+fenbendazole&hl=en&gl=us&ct=clnk&cd=9&client=firefox-a


Tweet