Glad you jumped back in, Milliecake. Send your brother a big encouragement from me to do the enemas. As a high copper gal, they have made a powerful difference in coping with the symptoms. I don't know how copper affects your brother, but I can feel "wired", emotional, tired, spacey, headachy, etc., and that enema can provide huge relief. A lot of people doing NB try them with reluctance, and most end up swearing by them. I didn't have an aversion to trying one because I had a sense that the supplements were causing more detox, and my body didn't have the best outlets for it. In my case, I was struggling with constipation and also didn't sweat. He may be doing well in those areas which will help with detoxification. Even so, enemas would provide extra relief.