When the LBB is not correcting your problems up the dosage.... I was taking near 18 a day when I first started my Intestinal Cleansing... I have been a Fruitarian for 6 months and still HAVE to use the LBB, if not I am constipated!! Which means no bowel movement... Dr. Christopher suggests to use the LBB for 8-12 months to strengthen the intestines.... MH also suggests this amount of time... If the "way of eating" is only fruits then with due time you may stop using the LBB.... If the "way of eating" is never only fruits the LBB will be a life long herbal formula.