I'd suggest to spread out your dosage over the day. I once took about 30 drops of 5% Lugol's in the beginning of my Iodine supplementation and it was quite intense on my stomach. Having said that, SSKI in high dosages is a lot easier to 'stomach' but you still can get pretty strong detox too when SSKI is taken in dropperfulls several times a day - got my eyelids swollen badly and huge sinus discharge for several days straight until I reduced the dosage. It was just my experimentation of how much I could handle. Obviously, it was bromide coming out of the system.