Regardless of where the candida is, once your body becomes tolerant to the candida, it will give you symptoms via the toxins in your bloodstream. The reason for doing the nystatin enemas and other kinds of enemas that clean out the colon, is to give your immune system a break from some of the toxins that are being delivered, so that it is better equipped to deal with them in the future. It also gives your body and organs a rest, and also clears out some colonies...ofcourse.