The roles niacin and niacinamide can play in the body's detox process

Yes, Chris, I think we are both on the same page pretty much on this one.  I would fast, cleanse and detox and then go back to the very basics.

Speaking of the human detox process, I though you might find this interesting regarding the two phase process and how two different forms of niacin can affect each part:

"Simply speaking, the body's natural liver detoxification process involves two steps; Phase 1 and Phase 2. A toxin initially enters Phase 1, the P-450 cytochrome system, and is reduced to smaller fragments. These fragments then progress to Phase 2, where they are bound to molecules such as glutathione, glycine and sulfate. This process creates a new non-toxic molecule that can be excreted in the bile, urine or stool.

In effect, Phase 1 either directly neutralizes a toxin, or modifies the toxic chemical to form activated intermediates which are then neutralized by one of more of the several Phase 2 enzyme systems. In Phase 1, a toxic chemical is converted into a less harmful chemical. This is achieved by various chemical reactions (such as oxidation, reduction and hydrolysis), and during this process free radicals are produced which, if excessive, can damage the liver cells. Antioxidants reduce the damage caused by these free radicals. If antioxidants are lacking and toxin exposure is high, toxic chemicals become far more dangerous. Some may be converted from relatively harmless substances into potentially carcinogenic substances.

One or both detoxification phases can be inefficient or overloaded. A particularly damaging combination in an ill person is an excessive overload of toxins coming into Phase 1, with an inefficient Phase 2. In some cases this combination is believed to be the cause of marked environmental sensitivities, drug intolerances and interactions that characterize many chronic fatigue and fibromyalgia patients."

http://www.diagnose-me.com/treat/T355489.html

Niacinamide slows down phase 1, while niacin speeds up phase 2.  Niacin is also known as inositol hexanicotinate, vitamin B3 and nicotinic acid.

The relevance to this thread, besides the harm that may be caused from an overload of toxins and the creation of free radicals and carcinogens and such, is that when a body's primary detox system is not functioning well in one or both phases, then toxins may bypass the normal detox outlets of first of all the liver and bile duct and secondly the kidneys, and then seek elimination through the body's third method of toxin elimination, which is the skin.

All the best,

Tony