I used to go through pretty bad die-off. Since I adopted a pretty much permanent anti-candida diet, taken lots of antifungals, repopulate every day with good probiotics, I no longer have any die-off and thus would think I have it under control. I can take all the anti-fungals threelac whatever it is I want without feeling anything. I have fairly decent bowel movements as well I guess, not that anyone wanted to know.