i am not speaking from personal experience but from intuition, having never taken anything stronger than ibuprofen. I am guessing that as long as you are not CURRENTLY taking any medication, you are safe to begin UT. i would think that anything in your system would be flushed more quickly while doing UT. Even though it is not recommended, i occasionally have a beer or two and i still practice UT. It doesn't seem to have any ill effect. I have found that drinking urine helps to expediate to detoxification process.