Yes, i do agree with you on the guess work of how much cream to apply. I stopped using it because my blood pressure was high even though I had lost almost 30 pounds after removal. I looked sickly back then. My doctor suggested that the progesterone cream might have been raising my blood pressure. So I stopped using it. By then I think I was well enough to try coping without it. From what I remember I applied it just as it said to on the instructions. I recall one evening when I was especially sick with insomnia and high blood pressure ( I had bought a blood pressure monitor) that I applied the cream and miraculously the blood pressure went down and I slept like a baby. I do believe like many on this forum that Mirena screws your bodies ability to make its own natural progesterone after removal therefore you get the crash. Good luck with your recovery & I apologize for the late reply.