Just started on SAMe - 2--mg a day and to be honest I think I could go down to 100mg. I felt an immediate improvement in my energy level and mood, but last night I has a couple of drinks which helped me get to sleep but after that wore off I woke up at 3am and couldn't back to sleep. I don;t feel bad, but just couldn't sleep. HAs anyone else had interactions between SAMe and caffiene? I drink a lot of coffee too but it has not been keeping me awake like that.