I don't have goiter but I can say that taking 50mg of iodoral did nothing for my asthma. When I started experimenting with large doses of SSKI, I noticed an immediate improvement in my asthma. For the 1st time in 30 years, I don't need any more VERY EXPENSIVE inhalers.
SSKI is 30mg per drop. I suggest starting with a squirt per day (about 400mg). Maybe your thyroid will react like my lungs did, I think it is worth a try. It can't hurt.
So I continue to take 50mg iodoral and I take 2 squirts of SSKI daily (about 800mg).
PS) One of my favorite sources of information, Wicki said this: " If goiter is untreated for around five years, however, iodine supplementation or thyroxine treatment may not reduce the size of the thyroid gland because the thyroid is permanently damaged."