I don't know if this helps but I found that my thyroid plays a major role in detoxing estrogen and it seems like copper as well. I wonder if a detox with more concentration on thyroid or even getting the liver and kidneys to do their job more would be a better approach. Or maybe you have already tried that.
I used Relora to get my Cortisol down. I also use milk thistle and livercare to improve my liver function.