Re: More Iodine requires more magnesium???

Don't know about needing more magnesium, but iodolactones are lipids with incorporated iodine.

http://www.iodine4health.com/special/physiology/compounds/iodolipids.htm

Iodolipids

Iodolipids are iodinated lipids -- i.e., lipids (fats) with incorporated iodine.

The requirements for the formation of iodolipids are (1) a peroxidase, (2) an elevated concentration of iodide and (3) hydrogen peroxide. These conditions can be met in various places in the body, including the thyroid, mammary gland, oviduct, and uterus.

Iodolactones.

Iodolactones consist of polyunsaturated fatty acids such as arachidonic acid (AA), eicosapentaenoic acid (EPA). and docosahexaenoic acid (DHA).

The delta-iodolactones of arachidonic acid inhibits the EGF (Epidermal Growth Factor) receptor.  When the EGF receptor is inhibited, the metabolism of arachidonic acid induced by EGF (and TGF-a) is inhibited.  This inhibition suppresses goiter formation and can induce involution (shrinking the goiter).

The delta-iodolactone of eicosapentaenoic acid exerts an antiproliferative effect in the nanomolar range.

Neither arachidonic acid by itself nor other iodolactones (besides delta-iodolactones) have this antiproliferative effect.

The synthesis of delta-iodolactone from arachidonic acid, iodine, and H2O2 is catalyzed by peroxidases.  Thus, iodolactone formation is not limited to the thyroid gland but can occur in any organ that contains peroxidases (e.g., the breast).