A lot of stress, a lot of O2, CO2 low
higher pressure + bad diet (too many carbs) ect
However, for Practical Purposes, dilation of arteries and arterioles has the most Significant Therapeutic value since Blood Vessels These are the main contributors to systemic vascular resistance and, Therefore, dilation of arteries and arterioles leads to an Immediate Decrease in arterial blood pressure and heart rate (hence, chemical arterial dilators are used to treat heart failure, pulmonary hypertension and systemic, and angina).