If you want to use a huge bottle of 5% solution go ahead. I would just not go above 5 drops of Humbles 28% solution instead. If you need more just take more doses during the day. There are many happy taking 15 drop doses though. One started at a 1/2 drop and slowly worked up over many months. Another cleared up his/hers colitis taking at most 12 drops once a day, then finished the job with Iodine.