The safety and effectiveness of oleander extract
I agree that the raw plant is highly toxic and your warning that it should not be fooled with unless you know what you are doing is a good one. Fortunately, I happen to know very well what I am doing when it comes to oleander, probably better than 99.999% of the people on the planet. In addition to researching it and having written a book about it, I have hosted a Yahoo health group about it (Oleandersoup) for the past five years which now contains almost 1,000 members, many of whom have made the home remedy version.
Oleander extract made according to proper directions retains less than 2% of the cardiac glycosides you mention (and oleander actually contains many more than just 3 cardiac glycosides, btw). Each dose of oleander contains about 1/40th of the amount of cardiac glycosides in a typical dose of digoxin/digitalis. One patented medicine made essentially the same way as the home remedy (which is itself based on the original patent) has been used for over 40 years now and has passed FDA phase I toxicity tests. The results were that no limiting dose was arrived at due to toxicity, but rather they stopped increasing the dose when the amount became so large as to be impractical to administer.
In addition to the patented medicine version, plus another new version which uses a different extraction method and is in the middle of successful phase I trials at MD Anderson, there are now two herbal supplements based on oleander - both of which use the same aqueous extraction method as the home remedy version and patented medicine version.
Thousands of people around the world have now used the patented medicine, home remedy and herbal supplement versions for cancer, HIV, hepatitis and other mutagenic and immune disorder and there has not been one single life threatening side effect or event associated with properly made and administered oleander extract.
To learn more about oleander, I suggest the following articles I authored which have been widely published and distributed in such venues as Natural News, The American Chronicle and the Crusader:
An Amazing Discovery in Turkey
The Father of Oleander Soup
The History of Oleander Before 1960
Success Against Cancer and HIV in South Africa
The Recipe for Oleander Soup Part 1
The Recipe for Oleander Soup Part 2 - Tips and Advice
Oleander Induces Autophagy - Exclusive Story
The Newman Studies on Oleander
Herbal Supplement for HIV/AIDS is Successful in Clinical Trial
As a final note - to be safe, no one should take oleander without the supervision of a qualified care practitioner if they are also taking a medication which contains cardiac glycosides or a blood thinner medication such as Wayfarin/Coumadin. And no one should attempt to make their own extract unless they will follow the directions without improvisation.
DQ