Re: All chelators move some mercury into the brain from the body.

HOW CARNOSINE PROTECTS AGAINST BRAIN DEGENERATION*

The brain's rich supply of oxygen, glucose, membrane lipids and metals may explain why it is also richly endowed with carnosine. Carnosine suppresses oxidative stress, lipid peroxidation, pathological protein-sugar interactions and copper-zinc toxicity. Moreover, carnosine's ability to forestall cellular senescence may help sustain the long lives of neurons, which do not divide to form new cells.

A major source of oxidative damage and cellular dysfunction in the brain is the oxidation of lipids in the membranes of brain cells.* This generates highly toxic byproducts that damage proteins and inhibit the synthesis of protein and DNA. Lipid peroxidation is particularly significant in Alzheimer's disease, where it is most prominent in the vicinity of senile plaques.** Carnosine dramatically reduces the levels of lipid peroxidation products.

When mice were stressed with electric shocks for two hours, significant increases in lipid peroxidation products in the brain and blood were observed, with decreased antioxidant activity levels.*** However, mice treated with carnosine before the shocks showed opposite effects. After the same series of shocks, their brain and blood lipid peroxidation product levels were more than 85% lower than in the untreated mice. Brain SOD antioxidant activity was six times higher in the carnosine fed mice compared to the untreated mice. When stress was induced, it caused a Depression in levels of essential membrane phospholipids by 9% while carnosine treatment actually raised them by 26%. Carnosine also protected against a step in the glycation process, protected cells from damage by lipid peroxidation toxins and increased the "flowability" of cell membranes.

In Alzheimer's disease, lipid peroxidation toxins are thought to interfere with critical membrane proteins involved in cellular signaling and in transporting ions, glucose and glutamate. Carnosine appears to protect against many of the pathologies that have been identified in the Alzheimer's disease process.


http://www.health-marketplace.com/Article-Carnosine.htm
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