I have had Me/CFS for seven years now, and I was put on doxycycline for a year according to Dr Garth Nicholsons protocol. I couldn't do more than 4 months. After that, my ligaments and perhaps bones seemed to get even weaker and I got chronic constipation which was really bad. I felt a little better during the protocol in the beginning, I could walk all of a sudden, couldn't do that at all before, but the sideeffects can be after a long time of using it, really bad. For me pure oregano oil has been beneficial but everyone is different. All the herbal Antibiotics tend to be much better then the synthetic drugs. I never felt any better with migraines and such on the protocol, only my body was getting somewhat stronger.