The Wolff Chaikof Effect: Crying Wolf?
Guy E Abraham, M.D.
In 1948, Wolff and Chaikoff published a landmark paper (1), on the thyroid effect of increasing amounts of Iodide (Potassium salt), injected intraperitoneally in rats. The authors stated: “Organic binding of Iodine within the glands can be almost completely blocked by raising the level of plasma inorganic Iodine (PII) above a certain critical level, which for the rat amounts to about 20 to 35 percent.” This effect became known as the Wolff-Chaikoff (W-C) Effect.