I was on ortho tri cycline for 3 months and it did nothing to clear up my skin. My alternative medicine doctor told me to come off that immediately when i started to see him because in some causes - especially mine it can make it worse- you are so much better off treating Acne from the inside out - and naturally through diets and cleanses- this is coming from someone who has tried EVERYTHING. It took me two years to figure that out - Acne is cause most often by problems with your digestive system