Re: World Nut Daily

We must use different methods of reading.

Excerpts from:

Early Downward Trends in Neurodevelopmental Disorders Following Removal of Thimerosal-Containing Vaccines

David A. Geier, B.A.
Mark R. Geier, M.D., Ph.D.

Contemporaneously with the epidemic rise in neurodevelopmental disorders (NDs), first observed in the United States during the 1990s, the childhood immunization schedule was expanded by the U.S. Centers for Disease Control and Prevention (CDC) to include several additional thimerosal-containing vaccines (TCVs). On July 7, 1999, a joint recommendation was made by the American Academy of Pediatrics (AAP) and the U.S. Public Health Service (PHS) to remove thimerosal from vaccines. A two-phase study was undertaken to evaluate trends in diagnosis of new NDs entered into the Vaccine Adverse Event Reporting System (VAERS) and the California Department of Developmental Services (CDDS) databases on a reporting quarter basis, from 1994 through 2005. Significant increasing trends in newly diagnosed NDs were observed in both databases 1994 through mid-2002. Significant decreasing trends in newly diagnosed NDs were observed in both databases from mid-2002 through 2005. The results indicate that the trends in newly diagnosed NDs correspond directly to the expansion and subsequent contraction of the cumulative mercury dose to which children were exposed from TCVs through the U.S. immunization schedule.

The findings of the present study are also further supported by recent clinical studies examining the body burden of mercury and mercury susceptibility in children with NDs. Bradstreet et al. showed that, following chelation, urinary concentration of mercury was significantly greater, by a factor of approximately six, in autistic children compared with neurotypical children, whereas urinary cadmium and lead concentrations were similar. Matched vaccinated and unvaccinated neurotypical children had similar urinary mercury concentration following chelation. Holmes et al. examined first baby haircuts and determined that autistics had significantly higher body burdens of mercury in comparison to nonautistic matched controls, by demonstrating that the mercury level in hair, and thus the ability to excrete mercury, was inversely proportional to the severity of autism and overall much lower in the autistic group. James et al. have evaluated biochemical susceptibility to mercury in autistic children, in comparison to age-and gender-matched control children, by evaluating the methionine cycle and transsulfuration metabolites. They found a significant 46% decrease in the plasma concentration of glutathione, a necessary metabolite for the excretion of mercury from the body. Additionally, autistic children had significantly increased oxidative stress, as shown by a three-fold decrease in the glutathione/oxidized glutathione redox ratio, in comparison to control children, which would correlate with a significant body burden of mercury.

Conclusions
 
The present controlled assessment of VAERS and CDDS databases shows that very specific NDs are associated with TCVs. This conflicts with the 2004 conclusions of the IOM, largely based upon examination of vaccine safety data from the National Immunization Program (NIP) of the CDC. The IOM stated that the evidence favored rejection of a causal relationship between thimerosal and autism, that such a relationship was not biologically plausible, and that no further studies should be conducted to evaluate it.
 
From data presented here and other emerging data, it appears clear that additional research should be undertaken concerning the effects of mercury exposure, particularly from TCVs. This is especially true in light of the fact that the handling of vaccine safety data by the NIPhas recently been called into question by the IOM.

Should you need further evidence, I suggest following these links at theNational Autism Association library: (http://www.nationalautismassociation.org/library.php):

Note the highlighted refutation of the study you posted earlier:

Bibliography of Thimerosal, Immune and Gastrointestinal Studies that NAA feels are relevant.
May 2005

Evidence of Collusion

The National Vaccine Advisory Committee Sponsored Workshop on Thimerosal Vaccines
Day One, Day Two
and
Scientific Review of Vaccine Safety Datalink Information
The Simpsonwood Documents
Safe Mind’s Assessment
The Simpsonwood Documents (selected quotes)

Thimerosal

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to
Methylmercury or Vaccines Containing Thimerosal
This NIH-funded study, conducted by Dr. Thomas Burbacher, a University of Washington researcher, found that Thimerosal, best known for its use as an ethylmercury-based preservative in infant vaccines and pregnancy shots, is actually more toxic to the brain than methylmercury (MeHg).

Comparison of organic and inorganic mercury distribution in suckling rat
Published in the Journal of Applied Toxicology

Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
Jill James, et al - November 2004

A published study showing genetically susceptible mice will develop autistic symptoms when exposed to thimerosal.
Neurotoxic effects of postnatal thimerosal are mouse strain dependent.

Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway
Apoptosis in T Cells by Thimerosal 3/03

Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts.
Baskin Thimerosal Study 6/03

Thimerosal-Containing Vaccines and Neurodevelopment Outcomes
Boyd Haley Affidavit 9/03

This study presents the first epidemiologic evidence, based upon tens of millions of doses of vaccine administered in the United States, that associates increasing Thimerosal from vaccines with neurodevelopmental disorders.
Neurodevelopmental Disorders after TCV's - Geiers

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
Deth and Waley Molecular Psychiatry 2004

This analysis describes the concerns which Safe Minds has over a recently published study in The Lancet by Michael Pichichero et al.(1) in which blood measurements were taken of infants after administration of vaccines containing thimerosal. The article and accompanying commentary contain several sweeping statements about thimerosal safety:
Safe Minds Assessment of the Pichichero Thimerosal Study

Eli Lilly - Thimerosal Material Safety Data Sheet
Revised in June, 1991

Immunoadsorption is increasingly used to treat antibody-mediated autoimmune diseases.To prevent microbial growth during storage, reusable protein A gel columns are primed with ethyl mercury thiosalicylate (thiomersal,0.1% solution) and rinsed with phosphate buffer before use. In this study,we tested the hypothesis of systemic mercury exposure in protein A immunoadsorption
Thimerosal Exposure in Immuno adsorption Austria 1-04

Effect of thimerosal, a preservative in vaccines, on intracellular Ca(2+) concentration of rat cerebellar neurons
Toxicology 1-04

Danish Thimerosal-Autism Study in Pediatrics: Misleading and Uninformative on Autism-Mercury Link by Mark Blaxill (NOTE: This is a refutation of the study you posted)
Danish Thimerosal Autism Study

Failure of inactivated influenza A vaccine to protect healthy children aged 6 to 24 months - Is the CDC recommending exposure to thimerosal for an ineffective vaccine?

Pediatrics International - August 2003

Flu Vaccine

Failure of inactivated influenza A vaccine to protect healthy children aged 6-24 months
Published in Pediatrics International

Effectiveness of Influenza Vaccine during Pregnancy in Preventing Hospitalizations and Outpatient Visits for Respiratory Illness in Pregnant Women and Their Infants
Published in the American Journal of Perinatology
 

MMR

Commentary: MMR and Autism in Perspective: the Denmark Story

An Investigation of the Association Between MMR Vaccination and Autism in Denmark 8/04

This study is the latest in a series that examines the relationship between persistent measles virus infection and regressive autism.
Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism:  a Report of Three Cases.

Elevated Levels of Measles Antibodies in Children with Autism
Singh Elevated MV Antibody Titers 2003

Assessment of the Denmark MMR-Autism Study
Denmark MMR Study Assessment
 

Vaccine Safety Datalink

Generation Zero Full Analysis with Charts - Safe Minds 2004
Thomas Verstraeten’s First Analyses of the Link Between
Vaccine Mercury Exposure and the Risk of Diagnosis of
Selected Neuro-Developmental Disorders Based on Data from
the Vaccine Safety Datalink: November-December 1999

Generation Zero Synopsis - Safe Minds 2004

Verstraeten - It Just Won't Go Away

Vaccine Safety Datalink Study, Feb. 2000 (Generation 1)
Author, Thomas Verstraten. CDC study examining the link between thimerosal containing vaccines and neurodevelopmental disorders.

Vaccine Safety Datalink Study, June. 2000 (Generation 2)
The latest variation of Verstraeten's study which was discussed at Simpsonwood.

A CDC official who helped write the study accepted the critics charge that it contained many children too young to be diagnosed as autistic. “This is true, said scientist Frank DeStefano”
Missing the Mercury Menace, National Journal 1/04

Analysis and critique of the CDC’s handling of the Thimerosal exposure assessment based on vaccine safety datalink (VSD) information
VSD SafeMinds Critique

Aluminum

Aluminum in Vaccines
The Workshop on Aluminum in Vaccines, Puerto Rico, May 11, and 12, 2000
The full transcripts of a U.S. government-sponsored scientific meeting on aluminum and vaccines. The meeting raised concerns that aluminum may trigger adverse reactions. These are two large PDF files.
Part One - Part Two

Political Action

Letter to the Office of Special Counsel
Requesting an investigation of the FDA and CDC

 

Institute of Medicine

Statement of Rep. Dave Weldon, M.D., Member of Congress
Before the Institute of Medicine on February 9, 2004

 

Media Reports

RFK Jr. on Thimerosal in Vaccines
Uncut Interview with Sharyl Attkisson of CBS News
Click on CBS News RAW under Multimedia on the right side of the page.

Mercury Rising
A CBS News Report by Sharyl Atkisson

Toxic Tipping Point
by Andrea Rock, MotherJones.com  March/April 2004

The Not-So-Crackpot Autism Theory
Sunday's Magazine section, New York Times. By Arthur Allen. Nov. 11, 2002

 

Mercury Poisoning

Summary Comparison of Characteristics of Autism & Mercury Poisoning

Comparing autism versus mercury poisoning
Autism: a novel form of mercury poisoning

How Mercury Causes Brain Neuron Degeneration
Click here to view video from the University of Calgary.

A Case-Control Study of Mercury Burden in Children with Autistic Spectrum Disorders
Bradstreet Study 7/03

The Toxicology of Mercury — Current Exposures and Clinical Manifestations
Thomas W. Clarkson, Ph.D., Laszlo Magos, M.D., and Gary J. Myers, M.D.
New England Journal of Medicine, October 2003

Reduced Levels of Mercury in First Baby Haircuts of Autistic Children
First Baby Haircuts

A Report Prepared by the Staff of the Subcommittee on Human Rights and Wellness Committee on Government Reform United States House of Representatives
Mercury in Medicine 5/03

 

Autism Epidemic

The following is taken from the official State statistics produced by the Department of Education in the United States, for numbers of children aged 6-21 served by IDEA (Individuals With Disabilities Discrimination Act) who have autism. It compares the increase over the ten years between 1992-93 and 2003-04:
Autism Increase Rates in US by State

American Academy of Pediatrics
Autism A.L.A.R.M.

 

More Autism Studies

Oxidative Stress in Autism - November/December 2004
Woody R. McGinnis, MD

What’s Going On? The Question of Time Trends in Autism
Mark Blaxill, MBA - October 2004

Reduced violent behavior following biochemical therapy
William J. Walsh, Journal of Physiology & Behavior, June 2004

To investigate whether changes over time in the criteria used to diagnose CDER status 1 autism account for a significant proportion of the increased number of cases of autism.
Epidemiology of Autism in CA

Survey of novel recent findings
FDA - Developmental neurotoxicology of therapeutics

Statement by Martha R. Herbert, M.D., Ph.D.
Large Heads in Autism 7/03

A simple Google search will unearth many more:

Study: Vaccines' mercury causes autism-like signs in mice
http://www.laleva.org/eng/2004/06/study_vaccines_mercury_causes_autismlike_signs_in_mice.html

Roman Bystrianyk, "Study links vaccines containing mercury with autism", Health Sentinel, March 10, 2006,
http://www.healthsentinel.com/org_news.php?id=082&title=Study+links+vaccines+containing+mercury+with+autism&event=org_news_print_list_item

ScienceDaily: The Age of Autism: Study sees vaccine risk
http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20070626-16403000-bc-ageofautism.xml

etc.
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