Has your sister ever had Gonorrhea,Chlamydia or any other type of venereal infection?
can you provide info on bowel habits... eg.does she have say... three meals a day and three BM/day. Constipation or alternate between constipation/ Diarrhea etc.
When toxins escape through the intestinal wall (Leaky-Gut Syndrome) and are deposited elsewhere, this puts the immune system on red alert and depending were these toxins are deposited (ovaries) is where the immune system is going to attack.
We can look at alternative treatment for hormone replacement but for now we will concentrate on getting the immune system under controle.