If those are her only symptoms then it is not necessarily an autoimmune problem, although it could be one. I am a male and had the same problem with testosterone, although I had my problem my whole life. My testosterone production was nill. I am 39 and look way younger then that because I produce very little facial hair. I diidn't know there was a problem until this winter. I see an applied kinesiologist (AK). We tested my hormone levels with blood work and when it came back extremely low he put me on some homeopathic drops. It turned out that through muscle testing he could tell that my pituitary gland was not working properly and was shutting down production of some key hormones because it thought I was producing too much of them, when in fact I was producing almost none. Because my levels were so low I also went on a prescription testosterone cream, thinking I would use this until the homeopathics kicked in. Well my testicles started shrinking so I went off it after three days. That is the problem with hormone replacement therapy - it makes you produce less hormones because you are supplementing, which is very bad if you are already producing very little. It has been six months and my testosterone is well withing normal range, and I don't have to take daily supplements to keep it there. The homeopathics retrained my body to make more on a permanent basis. I am not going to try to diagnose your friends problem. My only point is that there are ways to increase hormones naturally without hormone replacement. I would recommend seeing an AK and having some muscle testing done. Not all AK's are created equally. You may have to see a few to find one that can fix endocrine problems. If it is an autoimmune problem then the AK might be able to offer a specific treatment to counteract it. Their protocols are tailored for each individual and are formulated through muscle testing to see what is good for the body.