i developed cystic Acne when i was 18, i tired it all, and eventually ended up on accutane. i will tell you that i personally had NO side effects except dry lips, dry nose and dry eyes. My Acne did not worsen, as they say it might after the first few weeks. It totally cleared me up for 8 years. About 6 months ago however, my cystic Acne returned. I am now on Accutane again. Ive been on it for 2 months and i feel fine. Some people do ended up taking more than one cycle of Accutane, but hey 8 years of clear skin isnt bad. Everything effects everyone differently, it has worked great for me! Good luck!!!